Accelerated protein synthesis via one–pot ligation–deselenization chemistry

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Accelerated protein synthesis via one–pot ligation–deselenization chemistry

Peptide ligation chemistry has revolutionized protein science by facilitating access to synthetic proteins. Here, we describe the development of additive-free ligation-deselenization chemistry at β-selenoaspartate and γ-selenoglutamate that enables the generation of native polypeptide products on un...

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Bibliographic Details
Main Authors:	Mitchell, Nicholas J., Sayers, Jessica, Kulkarni, Sameer S., Clayton, Daniel, Goldys, Anna M., Ripoll-Rozada, Jorge, Barbosa Pereira, Pedro José, Chan, Bun, Radom, Leo, Payne, Richard J.
Format:	Article
Published:	Elsevier 2017
Subjects:	peptide synthesis; selenium; proteins; quantum chemistry calculations
Online Access:	https://eprints.nottingham.ac.uk/42867/

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