Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population
The adrenal is a highly plastic organ with the ability to adjust to physiological needs by adapting hormone production but also by generating and regenerating both adrenocortical and adrenomedullary tissue. It is now apparent that many adult tissues maintain stem and progenitor cells that contribute...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Published: |
Elsevier
2015
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/42830/ |
| _version_ | 1848796578858401792 |
|---|---|
| author | Vukicevic, Vladimir Rubin de Celis, Maria Fernandez Pellegata, Natalia S. Bornstein, Stefan R. Androutsellis-Theotokis, Andreas Ehrhart-Bornstein, Monika |
| author_facet | Vukicevic, Vladimir Rubin de Celis, Maria Fernandez Pellegata, Natalia S. Bornstein, Stefan R. Androutsellis-Theotokis, Andreas Ehrhart-Bornstein, Monika |
| author_sort | Vukicevic, Vladimir |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The adrenal is a highly plastic organ with the ability to adjust to physiological needs by adapting hormone production but also by generating and regenerating both adrenocortical and adrenomedullary tissue. It is now apparent that many adult tissues maintain stem and progenitor cells that contribute to their maintenance and adaptation. Research from the last years has proven the existence of stem and progenitor cells also in the adult adrenal medulla throughout life. These cells maintain some neural crest properties and have the potential to differentiate to the endocrine and neural lineages. In this article, we discuss the evidence for the existence of adrenomedullary multi potent progenitor cells, their isolation and characterization, their differentiation potential as well as their clinical potential in transplantation therapies but also in pathophysiology. |
| first_indexed | 2025-11-14T19:50:13Z |
| format | Article |
| id | nottingham-42830 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:50:13Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-428302020-05-04T17:10:45Z https://eprints.nottingham.ac.uk/42830/ Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population Vukicevic, Vladimir Rubin de Celis, Maria Fernandez Pellegata, Natalia S. Bornstein, Stefan R. Androutsellis-Theotokis, Andreas Ehrhart-Bornstein, Monika The adrenal is a highly plastic organ with the ability to adjust to physiological needs by adapting hormone production but also by generating and regenerating both adrenocortical and adrenomedullary tissue. It is now apparent that many adult tissues maintain stem and progenitor cells that contribute to their maintenance and adaptation. Research from the last years has proven the existence of stem and progenitor cells also in the adult adrenal medulla throughout life. These cells maintain some neural crest properties and have the potential to differentiate to the endocrine and neural lineages. In this article, we discuss the evidence for the existence of adrenomedullary multi potent progenitor cells, their isolation and characterization, their differentiation potential as well as their clinical potential in transplantation therapies but also in pathophysiology. Elsevier 2015-06-15 Article PeerReviewed Vukicevic, Vladimir, Rubin de Celis, Maria Fernandez, Pellegata, Natalia S., Bornstein, Stefan R., Androutsellis-Theotokis, Andreas and Ehrhart-Bornstein, Monika (2015) Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population. Molecular and Cellular Endocrinology, 408 . pp. 178-184. ISSN 1872-8057 Adrenal medulla; Sympathoadrenal; Stem cells; Progenitor cells; ALDH; Hes3 http://www.sciencedirect.com/science/article/pii/S0303720714004237 doi:10.1016/j.mce.2014.12.020 doi:10.1016/j.mce.2014.12.020 |
| spellingShingle | Adrenal medulla; Sympathoadrenal; Stem cells; Progenitor cells; ALDH; Hes3 Vukicevic, Vladimir Rubin de Celis, Maria Fernandez Pellegata, Natalia S. Bornstein, Stefan R. Androutsellis-Theotokis, Andreas Ehrhart-Bornstein, Monika Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population |
| title | Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population |
| title_full | Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population |
| title_fullStr | Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population |
| title_full_unstemmed | Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population |
| title_short | Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population |
| title_sort | adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population |
| topic | Adrenal medulla; Sympathoadrenal; Stem cells; Progenitor cells; ALDH; Hes3 |
| url | https://eprints.nottingham.ac.uk/42830/ https://eprints.nottingham.ac.uk/42830/ https://eprints.nottingham.ac.uk/42830/ |