Methods for assessing the regenerative responses of neural tissue
In order to establish novel therapeutic paradigms and advance the field of regenerative medicine, methods for their effective implementation as well as rigorous assessment of outcomes are critical. This is especially evident and challenging in the context of treating complex and devastating neurodeg...
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| Format: | Book Section |
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Springer
2014
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| Online Access: | https://eprints.nottingham.ac.uk/42829/ |
| _version_ | 1848796578570043392 |
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| author | Poser, Steven W. Rueger, Maria Adele Androutsellis-Theotokis, Andreas |
| author2 | Christ, Bruno |
| author_facet | Christ, Bruno Poser, Steven W. Rueger, Maria Adele Androutsellis-Theotokis, Andreas |
| author_sort | Poser, Steven W. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In order to establish novel therapeutic paradigms and advance the field of regenerative medicine, methods for their effective implementation as well as rigorous assessment of outcomes are critical. This is especially evident and challenging in the context of treating complex and devastating neurodegenerative disorders, such as Parkinson’s disease, multiple sclerosis, and ischemic stroke. Stem cell-based approaches offer great promise in addressing these conditions. Here, we demonstrate an approach for identifying factors that mobilize endogenous neural stem cells in the repair and recovery of the central nervous system of rodents, involving site-specific administration of growth factors that activate particular signal transduction pathways, and that allows for the assessment of outcome utilizing magnetic resonance imaging and immunohistochemistry. |
| first_indexed | 2025-11-14T19:50:13Z |
| format | Book Section |
| id | nottingham-42829 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:50:13Z |
| publishDate | 2014 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-428292020-05-04T16:52:46Z https://eprints.nottingham.ac.uk/42829/ Methods for assessing the regenerative responses of neural tissue Poser, Steven W. Rueger, Maria Adele Androutsellis-Theotokis, Andreas In order to establish novel therapeutic paradigms and advance the field of regenerative medicine, methods for their effective implementation as well as rigorous assessment of outcomes are critical. This is especially evident and challenging in the context of treating complex and devastating neurodegenerative disorders, such as Parkinson’s disease, multiple sclerosis, and ischemic stroke. Stem cell-based approaches offer great promise in addressing these conditions. Here, we demonstrate an approach for identifying factors that mobilize endogenous neural stem cells in the repair and recovery of the central nervous system of rodents, involving site-specific administration of growth factors that activate particular signal transduction pathways, and that allows for the assessment of outcome utilizing magnetic resonance imaging and immunohistochemistry. Springer Christ, Bruno Oerlecke, Jana Stock, Peggy 2014-08-04 Book Section PeerReviewed Poser, Steven W., Rueger, Maria Adele and Androutsellis-Theotokis, Andreas (2014) Methods for assessing the regenerative responses of neural tissue. In: Animal models for stem cell therapy. Methods in molecular biology, V (1213). Springer, pp. 293-302. ISBN 9781493914531 Stem cells; Regenerative medicine; Neurodegeneration; Magnetic resonance imaging; Immunohistochemistry https://doi.org/10.1007/978-1-4939-1453-1_24 doi:10.1007/978-1-4939-1453-1_24 doi:10.1007/978-1-4939-1453-1_24 |
| spellingShingle | Stem cells; Regenerative medicine; Neurodegeneration; Magnetic resonance imaging; Immunohistochemistry Poser, Steven W. Rueger, Maria Adele Androutsellis-Theotokis, Andreas Methods for assessing the regenerative responses of neural tissue |
| title | Methods for assessing the regenerative responses of neural tissue |
| title_full | Methods for assessing the regenerative responses of neural tissue |
| title_fullStr | Methods for assessing the regenerative responses of neural tissue |
| title_full_unstemmed | Methods for assessing the regenerative responses of neural tissue |
| title_short | Methods for assessing the regenerative responses of neural tissue |
| title_sort | methods for assessing the regenerative responses of neural tissue |
| topic | Stem cells; Regenerative medicine; Neurodegeneration; Magnetic resonance imaging; Immunohistochemistry |
| url | https://eprints.nottingham.ac.uk/42829/ https://eprints.nottingham.ac.uk/42829/ https://eprints.nottingham.ac.uk/42829/ |