The STAT3-Ser/Hes3 signaling axis in cancer
Disrupting the regenerative capacity of tumorigenic cells is a major focus in medicine. These regenerative properties are carried by a subpopulation of cells within the tumor, termed cancer stem cells. Current therapies don't effectively tackle the disease suggesting these cells employ yet unid...
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| Format: | Article |
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Frontiers in Bioscience
2014
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| Online Access: | https://eprints.nottingham.ac.uk/42824/ |
| _version_ | 1848796577285537792 |
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| author | Poser, Steven Park, Deric M. Androutsellis-Theotokis, Andreas |
| author_facet | Poser, Steven Park, Deric M. Androutsellis-Theotokis, Andreas |
| author_sort | Poser, Steven |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Disrupting the regenerative capacity of tumorigenic cells is a major focus in medicine. These regenerative properties are carried by a subpopulation of cells within the tumor, termed cancer stem cells. Current therapies don't effectively tackle the disease suggesting these cells employ yet unidentified molecular mechanisms allowing them to evade targeting. Recent observations in neural stem cells reveal an extraordinary plasticity in the signaling pathways they utilize to grow. These findings are being extended to the cancer stem cell field, illuminating conceptually novel treatment strategies. Tumorigenic cells can make use of distinct, even opposing pathways, including JAK/STAT and the non-canonical STAT3-Ser/Hes3 signaling axis. This plasticity may not be confined to the cancer stem cell population, but may be shared by various cell types within the tumor, blurring the line distinguishing cancer stem cells from other tumor cell types. The implications to anti-cancer medicine are highly significant, since these findings demonstrate that inhibiting one cell growth pathway may actually enhance the activity of alternative ones. Drug discovery programs will also benefit from these concepts. |
| first_indexed | 2025-11-14T19:50:11Z |
| format | Article |
| id | nottingham-42824 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:50:11Z |
| publishDate | 2014 |
| publisher | Frontiers in Bioscience |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-428242020-05-04T16:40:21Z https://eprints.nottingham.ac.uk/42824/ The STAT3-Ser/Hes3 signaling axis in cancer Poser, Steven Park, Deric M. Androutsellis-Theotokis, Andreas Disrupting the regenerative capacity of tumorigenic cells is a major focus in medicine. These regenerative properties are carried by a subpopulation of cells within the tumor, termed cancer stem cells. Current therapies don't effectively tackle the disease suggesting these cells employ yet unidentified molecular mechanisms allowing them to evade targeting. Recent observations in neural stem cells reveal an extraordinary plasticity in the signaling pathways they utilize to grow. These findings are being extended to the cancer stem cell field, illuminating conceptually novel treatment strategies. Tumorigenic cells can make use of distinct, even opposing pathways, including JAK/STAT and the non-canonical STAT3-Ser/Hes3 signaling axis. This plasticity may not be confined to the cancer stem cell population, but may be shared by various cell types within the tumor, blurring the line distinguishing cancer stem cells from other tumor cell types. The implications to anti-cancer medicine are highly significant, since these findings demonstrate that inhibiting one cell growth pathway may actually enhance the activity of alternative ones. Drug discovery programs will also benefit from these concepts. Frontiers in Bioscience 2014-01-01 Article PeerReviewed Poser, Steven, Park, Deric M. and Androutsellis-Theotokis, Andreas (2014) The STAT3-Ser/Hes3 signaling axis in cancer. Frontiers in Bioscience, 19 (4). pp. 718-726. ISSN 1093-4715 http://www.bioscience.org/2014/v19/af/4238/list.htm doi:10.2741/4238 doi:10.2741/4238 |
| spellingShingle | Poser, Steven Park, Deric M. Androutsellis-Theotokis, Andreas The STAT3-Ser/Hes3 signaling axis in cancer |
| title | The STAT3-Ser/Hes3 signaling axis in cancer |
| title_full | The STAT3-Ser/Hes3 signaling axis in cancer |
| title_fullStr | The STAT3-Ser/Hes3 signaling axis in cancer |
| title_full_unstemmed | The STAT3-Ser/Hes3 signaling axis in cancer |
| title_short | The STAT3-Ser/Hes3 signaling axis in cancer |
| title_sort | stat3-ser/hes3 signaling axis in cancer |
| url | https://eprints.nottingham.ac.uk/42824/ https://eprints.nottingham.ac.uk/42824/ https://eprints.nottingham.ac.uk/42824/ |