Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia
Drug discovery and development are often hampered by lack of target identification and clinical tractability. Repurposing of approved drugs to life-threatening diseases such as leukemia is emerging as a promising alternative approach. Connectivity mapping systems link approved drugs with disease-rel...
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| Format: | Article |
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Springer Verlag
2014
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| Online Access: | https://eprints.nottingham.ac.uk/42819/ |
| _version_ | 1848796575874154496 |
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| author | Kettyle, Laura M.J. Liberante, Fabio G. Thompson, Alexander |
| author_facet | Kettyle, Laura M.J. Liberante, Fabio G. Thompson, Alexander |
| author_sort | Kettyle, Laura M.J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Drug discovery and development are often hampered by lack of target identification and clinical tractability. Repurposing of approved drugs to life-threatening diseases such as leukemia is emerging as a promising alternative approach. Connectivity mapping systems link approved drugs with disease-related gene signatures. Relevant preclinical models provide essential tools for system validation and proof-of-concept studies. Herein we describe procedures aimed at generating disease-based gene signatures and applying them to established cross-referencing databases of potential candidate drugs. As a proof of principle, we present the identification of Entinostat as a candidate drug for the treatment of HOX TALE-related leukemia. |
| first_indexed | 2025-11-14T19:50:10Z |
| format | Article |
| id | nottingham-42819 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:50:10Z |
| publishDate | 2014 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-428192020-05-04T16:51:21Z https://eprints.nottingham.ac.uk/42819/ Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia Kettyle, Laura M.J. Liberante, Fabio G. Thompson, Alexander Drug discovery and development are often hampered by lack of target identification and clinical tractability. Repurposing of approved drugs to life-threatening diseases such as leukemia is emerging as a promising alternative approach. Connectivity mapping systems link approved drugs with disease-related gene signatures. Relevant preclinical models provide essential tools for system validation and proof-of-concept studies. Herein we describe procedures aimed at generating disease-based gene signatures and applying them to established cross-referencing databases of potential candidate drugs. As a proof of principle, we present the identification of Entinostat as a candidate drug for the treatment of HOX TALE-related leukemia. Springer Verlag 2014-07-08 Article PeerReviewed Kettyle, Laura M.J., Liberante, Fabio G. and Thompson, Alexander (2014) Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia. Methods in Molecular Biology, 1196 . pp. 349-370. ISSN 1940-6029 HOXA9 Meis1 Data mining Gene expression profiles Connectivity mapping (sscMap) Leukemia Entinostat Preclinical model https://link.springer.com/protocol/10.1007%2F978-1-4939-1242-1_21 doi:10.1007/978-1-4939-1242-1_21 doi:10.1007/978-1-4939-1242-1_21 |
| spellingShingle | HOXA9 Meis1 Data mining Gene expression profiles Connectivity mapping (sscMap) Leukemia Entinostat Preclinical model Kettyle, Laura M.J. Liberante, Fabio G. Thompson, Alexander Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia |
| title | Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia |
| title_full | Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia |
| title_fullStr | Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia |
| title_full_unstemmed | Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia |
| title_short | Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia |
| title_sort | rational drug repurposing using sscmap analysis in a hox-tale model of leukemia |
| topic | HOXA9 Meis1 Data mining Gene expression profiles Connectivity mapping (sscMap) Leukemia Entinostat Preclinical model |
| url | https://eprints.nottingham.ac.uk/42819/ https://eprints.nottingham.ac.uk/42819/ https://eprints.nottingham.ac.uk/42819/ |