Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging
Background: Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study introduces the large ‘Nottingham Test Meal’ (NTM) for assessment of gastric motor and senso...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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Wiley
2016
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| Online Access: | https://eprints.nottingham.ac.uk/42810/ |
| _version_ | 1848796573376446464 |
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| author | Parker, H.L. Tucker, E. Hoad, Caroline Pal, A. Costigan, C. Hudders, N. Perkins, A. Blackshaw, E. Gowland, P. Marciani, L. Fox, M.R. |
| author_facet | Parker, H.L. Tucker, E. Hoad, Caroline Pal, A. Costigan, C. Hudders, N. Perkins, A. Blackshaw, E. Gowland, P. Marciani, L. Fox, M.R. |
| author_sort | Parker, H.L. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study introduces the large ‘Nottingham Test Meal’ (NTM) for assessment of gastric motor and sensory function by non-invasive imaging. Methods NTM comprises 400 mL liquid nutrient (0.75 kcal/mL) and 12 solid agar-beads (0 kcal) with known breaking strength. Gastric fullness and dyspeptic sensations were documented by 100 mm visual analogue scale (VAS). Gastric emptying (GE) were measured in 24 healthy volunteers (HVs) by gastric scintigraphy (GS) and magnetic resonance imaging (MRI). The contribution of secretion to gastric volume was assessed. Parameters that describe GE were calculated from validated models. Inter-observer agreement and reproducibility were assessed.
Key Results: NTM produced moderate fullness (VAS ≥30) but no more than mild dyspeptic symptoms (VAS <30) in 24 HVs. Stable binding of meal components to labels in gastric conditions was confirmed. Distinct early and late-phase GE were detected by both modalities. Liquid GE half-time was median 49 (95% CI: 36–62) min and 68 (57–71) min for GS and MRI, respectively. Differences between GS and MRI measurements were explained by the contribution of gastric secretion. Breaking strength for agar-beads was 0.8 N/m such that median 25 (8–50) % intact agar-beads and 65 (47–74) % solid material remained at 120 min on MRI and GS, respectively. Good reproducibility for liquid GE parameters was present and GE was not altered by agar-beads.
Conclusions & Inferences: The NTM provided an objective assessment of gastric motor and sensory function. The results were reproducible and liquid emptying was not affected by non-nutrient agar-beads. The method is potentially suitable for clinical practice. |
| first_indexed | 2025-11-14T19:50:08Z |
| format | Article |
| id | nottingham-42810 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:50:08Z |
| publishDate | 2016 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-428102024-08-15T15:18:45Z https://eprints.nottingham.ac.uk/42810/ Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging Parker, H.L. Tucker, E. Hoad, Caroline Pal, A. Costigan, C. Hudders, N. Perkins, A. Blackshaw, E. Gowland, P. Marciani, L. Fox, M.R. Background: Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study introduces the large ‘Nottingham Test Meal’ (NTM) for assessment of gastric motor and sensory function by non-invasive imaging. Methods NTM comprises 400 mL liquid nutrient (0.75 kcal/mL) and 12 solid agar-beads (0 kcal) with known breaking strength. Gastric fullness and dyspeptic sensations were documented by 100 mm visual analogue scale (VAS). Gastric emptying (GE) were measured in 24 healthy volunteers (HVs) by gastric scintigraphy (GS) and magnetic resonance imaging (MRI). The contribution of secretion to gastric volume was assessed. Parameters that describe GE were calculated from validated models. Inter-observer agreement and reproducibility were assessed. Key Results: NTM produced moderate fullness (VAS ≥30) but no more than mild dyspeptic symptoms (VAS <30) in 24 HVs. Stable binding of meal components to labels in gastric conditions was confirmed. Distinct early and late-phase GE were detected by both modalities. Liquid GE half-time was median 49 (95% CI: 36–62) min and 68 (57–71) min for GS and MRI, respectively. Differences between GS and MRI measurements were explained by the contribution of gastric secretion. Breaking strength for agar-beads was 0.8 N/m such that median 25 (8–50) % intact agar-beads and 65 (47–74) % solid material remained at 120 min on MRI and GS, respectively. Good reproducibility for liquid GE parameters was present and GE was not altered by agar-beads. Conclusions & Inferences: The NTM provided an objective assessment of gastric motor and sensory function. The results were reproducible and liquid emptying was not affected by non-nutrient agar-beads. The method is potentially suitable for clinical practice. Wiley 2016-03-24 Article PeerReviewed Parker, H.L., Tucker, E., Hoad, Caroline, Pal, A., Costigan, C., Hudders, N., Perkins, A., Blackshaw, E., Gowland, P., Marciani, L. and Fox, M.R. (2016) Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging. Neurogastroenterology & Motility, 28 (4). pp. 554-568. ISSN 1350-1925 Gastric emptying magnetic resonance imaging scintigraphy visceral sensitivity. http://onlinelibrary.wiley.com/doi/10.1111/nmo.12752/abstract doi:10.1111/nmo.12752 doi:10.1111/nmo.12752 |
| spellingShingle | Gastric emptying magnetic resonance imaging scintigraphy visceral sensitivity. Parker, H.L. Tucker, E. Hoad, Caroline Pal, A. Costigan, C. Hudders, N. Perkins, A. Blackshaw, E. Gowland, P. Marciani, L. Fox, M.R. Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging |
| title | Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging |
| title_full | Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging |
| title_fullStr | Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging |
| title_full_unstemmed | Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging |
| title_short | Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging |
| title_sort | development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging |
| topic | Gastric emptying magnetic resonance imaging scintigraphy visceral sensitivity. |
| url | https://eprints.nottingham.ac.uk/42810/ https://eprints.nottingham.ac.uk/42810/ https://eprints.nottingham.ac.uk/42810/ |