Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction

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Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction

Laminins are key basement membrane molecules that influence several biological activities and are linked to a number of diseases. They are secreted as heterotrimeric proteins consisting of one α, one β, and one γ chain, followed by their assembly into a polymer-like sheet at the basement membrane. U...

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Bibliographic Details
Main Authors:	Patel, Trushar R., Nikodemus, Denise, Besong, Tabot M.D., Reuten, Raphael, Meier, Markus, Harding, Stephen E., Winzor, Donald J., Koch, Manuel, Stetefeld, Jörg
Format:	Article
Published:	Elsevier 2016
Subjects:	Analytical ultracentrifugation; CD spectroscopy; Dynamic light scattering; Extracellular matrix; Laminin short arms; Protein self-association; Surface plasmon resonance
Online Access:	https://eprints.nottingham.ac.uk/42730/

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