Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects

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Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects

Tropomyosin 1 (TPM1) is an essential sarcomeric component, stabilising the thin filament and facilitating actin's interaction with myosin. A number of sarcomeric proteins, such as alpha myosin heavy chain, play crucial roles in cardiac development. Mutations in these genes have been linked to c...

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Bibliographic Details
Main Authors:	England, Jennifer, Granados-Riveron, Javier T., Polo-Parada, Luis, Kuriakose, Diji, Moore, Christopher, Brook, J. David, Rutland, Catrin S., Setchfield, Kerry, Gell, Christopher, Ghosh, Tushar K., Bu'Lock, Frances A., Thornborough, Christopher, Ehler, Elisabeth, Loughna, Siobhan
Format:	Article
Published:	Elsevier 2017
Subjects:	Cardiac development; Congenital heart defects; Structural protein; Tropomyosin 1
Online Access:	https://eprints.nottingham.ac.uk/42722/

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