Multipotent glia-like stem cells mediate stress adaptation
The neural crest-derived adrenal medulla is closely related to the sympathetic nervous system; however, unlike neural tissue, it is characterized by high plasticity which suggests the involvement of stem cells. Here, we show that a defined pool of glia-like nestin–expressing progenitor cells in the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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AlphaMed Press
2015
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| Online Access: | https://eprints.nottingham.ac.uk/42716/ |
| _version_ | 1848796551529365504 |
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| author | Rubin de Celis, Maria F. Garcia-Martin, Ruben Wittig, Dierk Valencia, Gabriela D. Enikolopov, Grigori Funk, Richard H. Chavakis, Triantafyllos Bornstein, Stefan R. Androutsellis-Theotokis, Andreas Ehrhart-Bornstein, Monika |
| author_facet | Rubin de Celis, Maria F. Garcia-Martin, Ruben Wittig, Dierk Valencia, Gabriela D. Enikolopov, Grigori Funk, Richard H. Chavakis, Triantafyllos Bornstein, Stefan R. Androutsellis-Theotokis, Andreas Ehrhart-Bornstein, Monika |
| author_sort | Rubin de Celis, Maria F. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The neural crest-derived adrenal medulla is closely related to the sympathetic nervous system; however, unlike neural tissue, it is characterized by high plasticity which suggests the involvement of stem cells. Here, we show that a defined pool of glia-like nestin–expressing progenitor cells in the adult adrenal medulla contributes to this plasticity. These glia-like cells have features of adrenomedullary sustentacular cells, are multipotent, and are able to differentiate into chromaffin cells and neurons. The adrenal is central to the body’s response to stress making its proper adaptation critical to maintaining homeostasis. Our results from stress experiments in vivo show the activation and differentiation of these progenitors into new chromaffin cells. In summary, we demonstrate the involvement of a new glia-like multipotent stem cell population in adrenal tissue adaptation. Our data also suggest the contribution of stem and progenitor cells in the adaptation of neuroendocrine tissue function in general. |
| first_indexed | 2025-11-14T19:49:47Z |
| format | Article |
| id | nottingham-42716 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:49:47Z |
| publishDate | 2015 |
| publisher | AlphaMed Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-427162020-05-04T17:08:18Z https://eprints.nottingham.ac.uk/42716/ Multipotent glia-like stem cells mediate stress adaptation Rubin de Celis, Maria F. Garcia-Martin, Ruben Wittig, Dierk Valencia, Gabriela D. Enikolopov, Grigori Funk, Richard H. Chavakis, Triantafyllos Bornstein, Stefan R. Androutsellis-Theotokis, Andreas Ehrhart-Bornstein, Monika The neural crest-derived adrenal medulla is closely related to the sympathetic nervous system; however, unlike neural tissue, it is characterized by high plasticity which suggests the involvement of stem cells. Here, we show that a defined pool of glia-like nestin–expressing progenitor cells in the adult adrenal medulla contributes to this plasticity. These glia-like cells have features of adrenomedullary sustentacular cells, are multipotent, and are able to differentiate into chromaffin cells and neurons. The adrenal is central to the body’s response to stress making its proper adaptation critical to maintaining homeostasis. Our results from stress experiments in vivo show the activation and differentiation of these progenitors into new chromaffin cells. In summary, we demonstrate the involvement of a new glia-like multipotent stem cell population in adrenal tissue adaptation. Our data also suggest the contribution of stem and progenitor cells in the adaptation of neuroendocrine tissue function in general. AlphaMed Press 2015-05-21 Article PeerReviewed Rubin de Celis, Maria F., Garcia-Martin, Ruben, Wittig, Dierk, Valencia, Gabriela D., Enikolopov, Grigori, Funk, Richard H., Chavakis, Triantafyllos, Bornstein, Stefan R., Androutsellis-Theotokis, Andreas and Ehrhart-Bornstein, Monika (2015) Multipotent glia-like stem cells mediate stress adaptation. STEM CELLS, 33 (6). pp. 2037-2051. ISSN 1549-4918 Nestin; Adult stem cells; Sustentacular cells; Stress; Plasticity; Neural stem cell-like cells; Adrenal medulla; Lineage tracing http://onlinelibrary.wiley.com/doi/10.1002/stem.2002/full doi:10.1002/stem.2002 doi:10.1002/stem.2002 |
| spellingShingle | Nestin; Adult stem cells; Sustentacular cells; Stress; Plasticity; Neural stem cell-like cells; Adrenal medulla; Lineage tracing Rubin de Celis, Maria F. Garcia-Martin, Ruben Wittig, Dierk Valencia, Gabriela D. Enikolopov, Grigori Funk, Richard H. Chavakis, Triantafyllos Bornstein, Stefan R. Androutsellis-Theotokis, Andreas Ehrhart-Bornstein, Monika Multipotent glia-like stem cells mediate stress adaptation |
| title | Multipotent glia-like stem cells mediate stress adaptation |
| title_full | Multipotent glia-like stem cells mediate stress adaptation |
| title_fullStr | Multipotent glia-like stem cells mediate stress adaptation |
| title_full_unstemmed | Multipotent glia-like stem cells mediate stress adaptation |
| title_short | Multipotent glia-like stem cells mediate stress adaptation |
| title_sort | multipotent glia-like stem cells mediate stress adaptation |
| topic | Nestin; Adult stem cells; Sustentacular cells; Stress; Plasticity; Neural stem cell-like cells; Adrenal medulla; Lineage tracing |
| url | https://eprints.nottingham.ac.uk/42716/ https://eprints.nottingham.ac.uk/42716/ https://eprints.nottingham.ac.uk/42716/ |