STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?
The endocrine system involves communication among different tissues in distinct organs, including the pancreas and components of the Hypothalamic- Pituitary-Adrenal Axis. The molecular mechanisms underlying these complex interactions are a subject of intense study as they may hold clues for the prog...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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Georg Thieme Verlag
2016
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| Online Access: | https://eprints.nottingham.ac.uk/42715/ |
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| author | Nikolakopoulou, P. Poser, S.W. Masjkur, J. Fernandez Rubin de Celis, M. Toutouna, L. Andoniadou, C.L. McKay, R.D. Chrousos, G. Ehrhart-Bornstein, M. Bornstein, S.R. Androutsellis-Theotokis, A. |
| author_facet | Nikolakopoulou, P. Poser, S.W. Masjkur, J. Fernandez Rubin de Celis, M. Toutouna, L. Andoniadou, C.L. McKay, R.D. Chrousos, G. Ehrhart-Bornstein, M. Bornstein, S.R. Androutsellis-Theotokis, A. |
| author_sort | Nikolakopoulou, P. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The endocrine system involves communication among different tissues in distinct organs, including the pancreas and components of the Hypothalamic- Pituitary-Adrenal Axis. The molecular mechanisms underlying these complex interactions are a subject of intense study as they may hold clues for the progression and treatment of a variety of metabolic and degenerative diseases. A plethora of signaling pathways, activated by hormones and other endocrine factors have been implicated in this communication. Recent advances in the stem cell field introduce a new level of complexity: adult progenitor cells appear to utilize distinct signaling pathways than the more mature cells in the tissue they co-reside. It is therefore important to elucidate the signal transduction requirements of adult progenitor cells in addition to those of mature cells. Recent evidence suggests that a common non-canonical signaling pathway regulates adult progenitors in several different tissues, rendering it as a potentially valuable starting point to explore their biology. The STAT3- Ser/Hes3 Signaling Axis was first identified as a major regulator of neural stem cells and, subsequently, cancer stem cells. In the endocrine/neuroendocrine system, this pathway operates on several levels, regulating other types of plastic cells: (a) it regulates pancreatic islet cell function and insulin release; (b) insulin in turn activates the pathway in broadly distributed neural progenitors and possibly also hypothalamic tanycytes, cells with important roles in the control of the adrenal gland; (c) adrenal progenitors themselves operate this pathway. The STAT3-Ser/Hes3 Signaling Axis therefore deserves additional research in the context of endocrinology. |
| first_indexed | 2025-11-14T19:49:47Z |
| format | Article |
| id | nottingham-42715 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:49:47Z |
| publishDate | 2016 |
| publisher | Georg Thieme Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-427152020-05-04T17:44:22Z https://eprints.nottingham.ac.uk/42715/ STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? Nikolakopoulou, P. Poser, S.W. Masjkur, J. Fernandez Rubin de Celis, M. Toutouna, L. Andoniadou, C.L. McKay, R.D. Chrousos, G. Ehrhart-Bornstein, M. Bornstein, S.R. Androutsellis-Theotokis, A. The endocrine system involves communication among different tissues in distinct organs, including the pancreas and components of the Hypothalamic- Pituitary-Adrenal Axis. The molecular mechanisms underlying these complex interactions are a subject of intense study as they may hold clues for the progression and treatment of a variety of metabolic and degenerative diseases. A plethora of signaling pathways, activated by hormones and other endocrine factors have been implicated in this communication. Recent advances in the stem cell field introduce a new level of complexity: adult progenitor cells appear to utilize distinct signaling pathways than the more mature cells in the tissue they co-reside. It is therefore important to elucidate the signal transduction requirements of adult progenitor cells in addition to those of mature cells. Recent evidence suggests that a common non-canonical signaling pathway regulates adult progenitors in several different tissues, rendering it as a potentially valuable starting point to explore their biology. The STAT3- Ser/Hes3 Signaling Axis was first identified as a major regulator of neural stem cells and, subsequently, cancer stem cells. In the endocrine/neuroendocrine system, this pathway operates on several levels, regulating other types of plastic cells: (a) it regulates pancreatic islet cell function and insulin release; (b) insulin in turn activates the pathway in broadly distributed neural progenitors and possibly also hypothalamic tanycytes, cells with important roles in the control of the adrenal gland; (c) adrenal progenitors themselves operate this pathway. The STAT3-Ser/Hes3 Signaling Axis therefore deserves additional research in the context of endocrinology. Georg Thieme Verlag 2016-04-30 Article PeerReviewed Nikolakopoulou, P., Poser, S.W., Masjkur, J., Fernandez Rubin de Celis, M., Toutouna, L., Andoniadou, C.L., McKay, R.D., Chrousos, G., Ehrhart-Bornstein, M., Bornstein, S.R. and Androutsellis-Theotokis, A. (2016) STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? Hormone and Metabolic Research, 48 (02). pp. 77-82. ISSN 1439-4286 STAT3 Hes3 stem cells https://doi.org/10.1055/s-0041-111699 doi:10.1055/s-0041-111699 doi:10.1055/s-0041-111699 |
| spellingShingle | STAT3 Hes3 stem cells Nikolakopoulou, P. Poser, S.W. Masjkur, J. Fernandez Rubin de Celis, M. Toutouna, L. Andoniadou, C.L. McKay, R.D. Chrousos, G. Ehrhart-Bornstein, M. Bornstein, S.R. Androutsellis-Theotokis, A. STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? |
| title | STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? |
| title_full | STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? |
| title_fullStr | STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? |
| title_full_unstemmed | STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? |
| title_short | STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? |
| title_sort | stat3-ser/hes3 signaling: a new molecular component of the neuroendocrine system? |
| topic | STAT3 Hes3 stem cells |
| url | https://eprints.nottingham.ac.uk/42715/ https://eprints.nottingham.ac.uk/42715/ https://eprints.nottingham.ac.uk/42715/ |