Structural brain correlates of adolescent resilience
Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Wiley
2016
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| Online Access: | https://eprints.nottingham.ac.uk/42636/ |
| _version_ | 1848796533381660672 |
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| author | Burt, Keith B. Whelan, Robert Conrod, Patricia J. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Fauth-Bühler, Mira Flor, Herta Galinowski, André Gallinat, Juergen Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomas Pausova, Zdenka Poustka, Luise Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh |
| author_facet | Burt, Keith B. Whelan, Robert Conrod, Patricia J. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Fauth-Bühler, Mira Flor, Herta Galinowski, André Gallinat, Juergen Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomas Pausova, Zdenka Poustka, Luise Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh |
| author_sort | Burt, Keith B. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background
Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification.
Methods
1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use.
Results
The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs.
Conclusions
We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity. |
| first_indexed | 2025-11-14T19:49:30Z |
| format | Article |
| id | nottingham-42636 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:49:30Z |
| publishDate | 2016 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-426362020-05-04T18:19:14Z https://eprints.nottingham.ac.uk/42636/ Structural brain correlates of adolescent resilience Burt, Keith B. Whelan, Robert Conrod, Patricia J. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Fauth-Bühler, Mira Flor, Herta Galinowski, André Gallinat, Juergen Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomas Pausova, Zdenka Poustka, Luise Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. Methods 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. Results The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. Conclusions We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity. Wiley 2016-11-30 Article PeerReviewed Burt, Keith B., Whelan, Robert, Conrod, Patricia J., Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Fauth-Bühler, Mira, Flor, Herta, Galinowski, André, Gallinat, Juergen, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Mann, Karl, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Paus, Tomas, Pausova, Zdenka, Poustka, Luise, Rietschel, Marcella, Robbins, Trevor W., Smolka, Michael N., Ströhle, Andreas, Schumann, Gunter and Garavan, Hugh (2016) Structural brain correlates of adolescent resilience. Journal of Child Psychology and Psychiatry, 57 (11). pp. 1287-1296. ISSN 1469-7610 http://onlinelibrary.wiley.com/doi/10.1111/jcpp.12552/abstract doi:10.1111/jcpp.12552 doi:10.1111/jcpp.12552 |
| spellingShingle | Burt, Keith B. Whelan, Robert Conrod, Patricia J. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Fauth-Bühler, Mira Flor, Herta Galinowski, André Gallinat, Juergen Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomas Pausova, Zdenka Poustka, Luise Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh Structural brain correlates of adolescent resilience |
| title | Structural brain correlates of adolescent resilience |
| title_full | Structural brain correlates of adolescent resilience |
| title_fullStr | Structural brain correlates of adolescent resilience |
| title_full_unstemmed | Structural brain correlates of adolescent resilience |
| title_short | Structural brain correlates of adolescent resilience |
| title_sort | structural brain correlates of adolescent resilience |
| url | https://eprints.nottingham.ac.uk/42636/ https://eprints.nottingham.ac.uk/42636/ https://eprints.nottingham.ac.uk/42636/ |