The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts
U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches. A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 pr...
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| Format: | Article |
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European Respiratory Society
2015
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| Online Access: | https://eprints.nottingham.ac.uk/42635/ |
| _version_ | 1848796533094350848 |
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| author | Fleming, Louise Murray, Clare Bansal, Aruna T. Hashimoto, Simone Bisgaard, Hans Bush, Andrew Frey, Urs Hedlin, Gunilla Singer, Florian Aalderen, Wim M. van Vissing, Nadja H. Zolkipli, Zaraquiza Selby, Anna Fowler, Stephen Shaw, Dominick E. Chung, Kian Fan Sousa, Ana R. Wagers, Scott Corfield, Julie Pandis, Ioannis Rowe, Anthony Formaggio, Elena Sterk, Peter J. Roberts, Graham |
| author_facet | Fleming, Louise Murray, Clare Bansal, Aruna T. Hashimoto, Simone Bisgaard, Hans Bush, Andrew Frey, Urs Hedlin, Gunilla Singer, Florian Aalderen, Wim M. van Vissing, Nadja H. Zolkipli, Zaraquiza Selby, Anna Fowler, Stephen Shaw, Dominick E. Chung, Kian Fan Sousa, Ana R. Wagers, Scott Corfield, Julie Pandis, Ioannis Rowe, Anthony Formaggio, Elena Sterk, Peter J. Roberts, Graham |
| author_sort | Fleming, Louise |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches.
A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 preschoolers with mild/moderate wheeze in a cross-sectional study.
Despite high-dose treatment, the severe cohorts had more severe exacerbations compared with the mild/moderate ones (annual medians: school-aged 3.0 versus 1.1, preschool 3.9 versus 1.8; p<0.001). Exhaled tobacco exposure was common in the severe wheeze cohort. Almost all participants in each cohort were atopic and had a normal body mass index. Asthma-related quality of life, as assessed by the Paediatric Asthma Quality of Life Questionnaire (PAQLQ) and the Paediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ), was worse in the severe cohorts (mean±SE school-age PAQLQ: 4.77±0.15 versus 5.80±0.19; preschool PACQLQ: 4.27±0.18 versus 6.04±0.18; both p≤0.001); however, mild/moderate cohorts also had significant morbidity. Impaired quality of life was associated with poor control and airway obstruction. Otherwise, the severe and mild/moderate cohorts were clinically very similar.
Children with severe preschool wheeze or severe asthma are usually atopic and have impaired quality of life that is associated with poor control and airflow limitation: a very different phenotype from adult severe asthma. In-depth phenotyping of these children, integrating clinical data with high-dimensional biomarkers, may help to improve and tailor their clinical management. |
| first_indexed | 2025-11-14T19:49:29Z |
| format | Article |
| id | nottingham-42635 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:49:29Z |
| publishDate | 2015 |
| publisher | European Respiratory Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-426352024-08-12T15:27:09Z https://eprints.nottingham.ac.uk/42635/ The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts Fleming, Louise Murray, Clare Bansal, Aruna T. Hashimoto, Simone Bisgaard, Hans Bush, Andrew Frey, Urs Hedlin, Gunilla Singer, Florian Aalderen, Wim M. van Vissing, Nadja H. Zolkipli, Zaraquiza Selby, Anna Fowler, Stephen Shaw, Dominick E. Chung, Kian Fan Sousa, Ana R. Wagers, Scott Corfield, Julie Pandis, Ioannis Rowe, Anthony Formaggio, Elena Sterk, Peter J. Roberts, Graham U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches. A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 preschoolers with mild/moderate wheeze in a cross-sectional study. Despite high-dose treatment, the severe cohorts had more severe exacerbations compared with the mild/moderate ones (annual medians: school-aged 3.0 versus 1.1, preschool 3.9 versus 1.8; p<0.001). Exhaled tobacco exposure was common in the severe wheeze cohort. Almost all participants in each cohort were atopic and had a normal body mass index. Asthma-related quality of life, as assessed by the Paediatric Asthma Quality of Life Questionnaire (PAQLQ) and the Paediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ), was worse in the severe cohorts (mean±SE school-age PAQLQ: 4.77±0.15 versus 5.80±0.19; preschool PACQLQ: 4.27±0.18 versus 6.04±0.18; both p≤0.001); however, mild/moderate cohorts also had significant morbidity. Impaired quality of life was associated with poor control and airway obstruction. Otherwise, the severe and mild/moderate cohorts were clinically very similar. Children with severe preschool wheeze or severe asthma are usually atopic and have impaired quality of life that is associated with poor control and airflow limitation: a very different phenotype from adult severe asthma. In-depth phenotyping of these children, integrating clinical data with high-dimensional biomarkers, may help to improve and tailor their clinical management. European Respiratory Society 2015-11-01 Article PeerReviewed Fleming, Louise, Murray, Clare, Bansal, Aruna T., Hashimoto, Simone, Bisgaard, Hans, Bush, Andrew, Frey, Urs, Hedlin, Gunilla, Singer, Florian, Aalderen, Wim M. van, Vissing, Nadja H., Zolkipli, Zaraquiza, Selby, Anna, Fowler, Stephen, Shaw, Dominick E., Chung, Kian Fan, Sousa, Ana R., Wagers, Scott, Corfield, Julie, Pandis, Ioannis, Rowe, Anthony, Formaggio, Elena, Sterk, Peter J. and Roberts, Graham (2015) The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts. European Respiratory Journal, 46 (5). pp. 1322-1333. ISSN 1399-3003 https://doi.org/10.1183/13993003.00780-2015 doi:10.1183/13993003.00780-2015 doi:10.1183/13993003.00780-2015 |
| spellingShingle | Fleming, Louise Murray, Clare Bansal, Aruna T. Hashimoto, Simone Bisgaard, Hans Bush, Andrew Frey, Urs Hedlin, Gunilla Singer, Florian Aalderen, Wim M. van Vissing, Nadja H. Zolkipli, Zaraquiza Selby, Anna Fowler, Stephen Shaw, Dominick E. Chung, Kian Fan Sousa, Ana R. Wagers, Scott Corfield, Julie Pandis, Ioannis Rowe, Anthony Formaggio, Elena Sterk, Peter J. Roberts, Graham The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts |
| title | The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts |
| title_full | The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts |
| title_fullStr | The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts |
| title_full_unstemmed | The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts |
| title_short | The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts |
| title_sort | burden of severe asthma in childhood and adolescence: results from the paediatric u-biopred cohorts |
| url | https://eprints.nottingham.ac.uk/42635/ https://eprints.nottingham.ac.uk/42635/ https://eprints.nottingham.ac.uk/42635/ |