Neural basis of reward anticipation and its genetic determinants
Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes...
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| Format: | Article |
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National Academy of Sciences
2016
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| Online Access: | https://eprints.nottingham.ac.uk/42632/ |
| _version_ | 1848796532251295744 |
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| author | Jia, Tianye Macare, Christine Desrivières, Sylvane Gonzalez, Dante A. Tao, Chenyang Ji, Xiaoxi Ruggeri, Barbara Nees, Frauke Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Bromberg, Uli Büchel, Christian Conrod, Patricia J. Dove, Rachel Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny A. Heinz, Andreas Ittermann, Bernd Lathrop, Mark Lemaitre, Hervé Martinot, Jean-Luc Paus, Tomáš Pausova, Zdenka Poline, Jean-Baptiste Rietschel, Marcella Robbins, Trevor Smolka, Michael N. Müller, Christian P. Feng, Jianfeng Rothenfluh, Adrian Flor, Herta Schumann, Gunter |
| author_facet | Jia, Tianye Macare, Christine Desrivières, Sylvane Gonzalez, Dante A. Tao, Chenyang Ji, Xiaoxi Ruggeri, Barbara Nees, Frauke Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Bromberg, Uli Büchel, Christian Conrod, Patricia J. Dove, Rachel Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny A. Heinz, Andreas Ittermann, Bernd Lathrop, Mark Lemaitre, Hervé Martinot, Jean-Luc Paus, Tomáš Pausova, Zdenka Poline, Jean-Baptiste Rietschel, Marcella Robbins, Trevor Smolka, Michael N. Müller, Christian P. Feng, Jianfeng Rothenfluh, Adrian Flor, Herta Schumann, Gunter |
| author_sort | Jia, Tianye |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature. |
| first_indexed | 2025-11-14T19:49:29Z |
| format | Article |
| id | nottingham-42632 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:49:29Z |
| publishDate | 2016 |
| publisher | National Academy of Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-426322020-05-04T17:47:47Z https://eprints.nottingham.ac.uk/42632/ Neural basis of reward anticipation and its genetic determinants Jia, Tianye Macare, Christine Desrivières, Sylvane Gonzalez, Dante A. Tao, Chenyang Ji, Xiaoxi Ruggeri, Barbara Nees, Frauke Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Bromberg, Uli Büchel, Christian Conrod, Patricia J. Dove, Rachel Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny A. Heinz, Andreas Ittermann, Bernd Lathrop, Mark Lemaitre, Hervé Martinot, Jean-Luc Paus, Tomáš Pausova, Zdenka Poline, Jean-Baptiste Rietschel, Marcella Robbins, Trevor Smolka, Michael N. Müller, Christian P. Feng, Jianfeng Rothenfluh, Adrian Flor, Herta Schumann, Gunter Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature. National Academy of Sciences 2016-04-05 Article PeerReviewed Jia, Tianye, Macare, Christine, Desrivières, Sylvane, Gonzalez, Dante A., Tao, Chenyang, Ji, Xiaoxi, Ruggeri, Barbara, Nees, Frauke, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Conrod, Patricia J., Dove, Rachel, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny A., Heinz, Andreas, Ittermann, Bernd, Lathrop, Mark, Lemaitre, Hervé, Martinot, Jean-Luc, Paus, Tomáš, Pausova, Zdenka, Poline, Jean-Baptiste, Rietschel, Marcella, Robbins, Trevor, Smolka, Michael N., Müller, Christian P., Feng, Jianfeng, Rothenfluh, Adrian, Flor, Herta and Schumann, Gunter (2016) Neural basis of reward anticipation and its genetic determinants. Proceedings of the National Academy of Sciences, 113 (14). pp. 3879-3884. ISSN 1091-6490 http://www.pnas.org/content/113/14/3879 doi:10.1073/pnas.1503252113 doi:10.1073/pnas.1503252113 |
| spellingShingle | Jia, Tianye Macare, Christine Desrivières, Sylvane Gonzalez, Dante A. Tao, Chenyang Ji, Xiaoxi Ruggeri, Barbara Nees, Frauke Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Bromberg, Uli Büchel, Christian Conrod, Patricia J. Dove, Rachel Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny A. Heinz, Andreas Ittermann, Bernd Lathrop, Mark Lemaitre, Hervé Martinot, Jean-Luc Paus, Tomáš Pausova, Zdenka Poline, Jean-Baptiste Rietschel, Marcella Robbins, Trevor Smolka, Michael N. Müller, Christian P. Feng, Jianfeng Rothenfluh, Adrian Flor, Herta Schumann, Gunter Neural basis of reward anticipation and its genetic determinants |
| title | Neural basis of reward anticipation and its genetic determinants |
| title_full | Neural basis of reward anticipation and its genetic determinants |
| title_fullStr | Neural basis of reward anticipation and its genetic determinants |
| title_full_unstemmed | Neural basis of reward anticipation and its genetic determinants |
| title_short | Neural basis of reward anticipation and its genetic determinants |
| title_sort | neural basis of reward anticipation and its genetic determinants |
| url | https://eprints.nottingham.ac.uk/42632/ https://eprints.nottingham.ac.uk/42632/ https://eprints.nottingham.ac.uk/42632/ |