Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity
Adolescence is a time that can set the course of alcohol abuse later in life. Sensitivity to reward on multiple levels is a major factor in this development. We examined 736 adolescents from the IMAGEN longitudinal study for alcohol drinking during early (mean age = 14.37) and again later (mean age...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/42623/ |
| _version_ | 1848796529732616192 |
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| author | Heinrich, Angela Müller, Kathrin U. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Conrod, Patricia Fauth-Bühler, Mira Papadopoulos, Dimitri Gallinat, Jürgen Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Martinot, Jean-Luc Paus, Tomáš Pausova, Zdenka Smolka, Michael Ströhle, Andreas Rietschel, Marcella Flor, Herta Schumann, Gunter Nees, Frauke |
| author_facet | Heinrich, Angela Müller, Kathrin U. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Conrod, Patricia Fauth-Bühler, Mira Papadopoulos, Dimitri Gallinat, Jürgen Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Martinot, Jean-Luc Paus, Tomáš Pausova, Zdenka Smolka, Michael Ströhle, Andreas Rietschel, Marcella Flor, Herta Schumann, Gunter Nees, Frauke |
| author_sort | Heinrich, Angela |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Adolescence is a time that can set the course of alcohol abuse later in life. Sensitivity to reward on multiple levels is a major factor in this development. We examined 736 adolescents from the IMAGEN longitudinal study for alcohol drinking during early (mean age = 14.37) and again later (mean age = 16.45) adolescence. Conducting structural equation modeling we evaluated the contribution of reward-related personality traits, behavior, brain responses and candidate genes. Personality seems to be most important in explaining alcohol drinking in early adolescence. However, genetic variations in ANKK1 (rs1800497) and HOMER1 (rs7713917) play an equal role in predicting alcohol drinking two years later and are most important in predicting the increase in alcohol consumption. We hypothesize that the initiation of alcohol use may be driven more strongly by personality while the transition to increased alcohol use is more genetically influenced. |
| first_indexed | 2025-11-14T19:49:26Z |
| format | Article |
| id | nottingham-42623 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:49:26Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-426232020-05-04T20:02:00Z https://eprints.nottingham.ac.uk/42623/ Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity Heinrich, Angela Müller, Kathrin U. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Conrod, Patricia Fauth-Bühler, Mira Papadopoulos, Dimitri Gallinat, Jürgen Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Martinot, Jean-Luc Paus, Tomáš Pausova, Zdenka Smolka, Michael Ströhle, Andreas Rietschel, Marcella Flor, Herta Schumann, Gunter Nees, Frauke Adolescence is a time that can set the course of alcohol abuse later in life. Sensitivity to reward on multiple levels is a major factor in this development. We examined 736 adolescents from the IMAGEN longitudinal study for alcohol drinking during early (mean age = 14.37) and again later (mean age = 16.45) adolescence. Conducting structural equation modeling we evaluated the contribution of reward-related personality traits, behavior, brain responses and candidate genes. Personality seems to be most important in explaining alcohol drinking in early adolescence. However, genetic variations in ANKK1 (rs1800497) and HOMER1 (rs7713917) play an equal role in predicting alcohol drinking two years later and are most important in predicting the increase in alcohol consumption. We hypothesize that the initiation of alcohol use may be driven more strongly by personality while the transition to increased alcohol use is more genetically influenced. Elsevier 2016-07 Article PeerReviewed Heinrich, Angela, Müller, Kathrin U., Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Conrod, Patricia, Fauth-Bühler, Mira, Papadopoulos, Dimitri, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Mann, Karl, Martinot, Jean-Luc, Paus, Tomáš, Pausova, Zdenka, Smolka, Michael, Ströhle, Andreas, Rietschel, Marcella, Flor, Herta, Schumann, Gunter and Nees, Frauke (2016) Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity. Biological Psychology, 118 . pp. 79-87. ISSN 1873-6246 Prediction of alcohol consumption; Adolescents; Longitudinal study; Personality; Behavior; Brain responses; Genetic variations http://www.sciencedirect.com/science/article/pii/S0301051116301818 doi:10.1016/j.biopsycho.2016.05.002 doi:10.1016/j.biopsycho.2016.05.002 |
| spellingShingle | Prediction of alcohol consumption; Adolescents; Longitudinal study; Personality; Behavior; Brain responses; Genetic variations Heinrich, Angela Müller, Kathrin U. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Conrod, Patricia Fauth-Bühler, Mira Papadopoulos, Dimitri Gallinat, Jürgen Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Martinot, Jean-Luc Paus, Tomáš Pausova, Zdenka Smolka, Michael Ströhle, Andreas Rietschel, Marcella Flor, Herta Schumann, Gunter Nees, Frauke Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity |
| title | Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity |
| title_full | Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity |
| title_fullStr | Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity |
| title_full_unstemmed | Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity |
| title_short | Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity |
| title_sort | prediction of alcohol drinking in adolescents: personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity |
| topic | Prediction of alcohol consumption; Adolescents; Longitudinal study; Personality; Behavior; Brain responses; Genetic variations |
| url | https://eprints.nottingham.ac.uk/42623/ https://eprints.nottingham.ac.uk/42623/ https://eprints.nottingham.ac.uk/42623/ |