Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?
The adrenal gland is a highly plastic organ with the capacity to adapt the body homeostasis to different physiological needs. The existence of stem-like cells in the adrenal cortex has been revealed in many studies. Recently, we identified and characterized in mice a pool of glia-like multipotent Ne...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/42618/ |
| _version_ | 1848796528374710272 |
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| author | Steenblock, Charlotte de Celis, Maria F. Rubin Androutsellis-Theotokis, Andreas Sue, Mariko Delgadillo Silva, Luis F. Eisenhofer, Graeme Andoniadou, Cynthia L. Bornstein, Stefan R. |
| author_facet | Steenblock, Charlotte de Celis, Maria F. Rubin Androutsellis-Theotokis, Andreas Sue, Mariko Delgadillo Silva, Luis F. Eisenhofer, Graeme Andoniadou, Cynthia L. Bornstein, Stefan R. |
| author_sort | Steenblock, Charlotte |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The adrenal gland is a highly plastic organ with the capacity to adapt the body homeostasis to different physiological needs. The existence of stem-like cells in the adrenal cortex has been revealed in many studies. Recently, we identified and characterized in mice a pool of glia-like multipotent Nestin-expressing progenitor cells, which contributes to the plasticity of the adrenal medulla. In addition, we found that these Nestin progenitors are actively involved in the stress response by giving rise to chromaffin cells. Interestingly, we also observed a Nestin-GFP-positive cell population located under the adrenal capsule and scattered through the cortex. In this article, we discuss the possibility of a common progenitor giving rise to subpopulations of cells both in the adrenal cortex and medulla, the isolation and characterization of this progenitor as well as its clinical potential in transplantation therapies and in pathophysiology. |
| first_indexed | 2025-11-14T19:49:25Z |
| format | Article |
| id | nottingham-42618 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:49:25Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-426182020-05-04T18:35:58Z https://eprints.nottingham.ac.uk/42618/ Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? Steenblock, Charlotte de Celis, Maria F. Rubin Androutsellis-Theotokis, Andreas Sue, Mariko Delgadillo Silva, Luis F. Eisenhofer, Graeme Andoniadou, Cynthia L. Bornstein, Stefan R. The adrenal gland is a highly plastic organ with the capacity to adapt the body homeostasis to different physiological needs. The existence of stem-like cells in the adrenal cortex has been revealed in many studies. Recently, we identified and characterized in mice a pool of glia-like multipotent Nestin-expressing progenitor cells, which contributes to the plasticity of the adrenal medulla. In addition, we found that these Nestin progenitors are actively involved in the stress response by giving rise to chromaffin cells. Interestingly, we also observed a Nestin-GFP-positive cell population located under the adrenal capsule and scattered through the cortex. In this article, we discuss the possibility of a common progenitor giving rise to subpopulations of cells both in the adrenal cortex and medulla, the isolation and characterization of this progenitor as well as its clinical potential in transplantation therapies and in pathophysiology. Elsevier 2017-02-05 Article PeerReviewed Steenblock, Charlotte, de Celis, Maria F. Rubin, Androutsellis-Theotokis, Andreas, Sue, Mariko, Delgadillo Silva, Luis F., Eisenhofer, Graeme, Andoniadou, Cynthia L. and Bornstein, Stefan R. (2017) Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? Molecular and Cellular Endocrinology, 441 . pp. 156-163. ISSN 1872-8057 adrenal medulla adrenal cortex stem cells progenitors stress nestin http://www.sciencedirect.com/science/article/pii/S0303720716303768 doi:10.1016/j.mce.2016.09.011 doi:10.1016/j.mce.2016.09.011 |
| spellingShingle | adrenal medulla adrenal cortex stem cells progenitors stress nestin Steenblock, Charlotte de Celis, Maria F. Rubin Androutsellis-Theotokis, Andreas Sue, Mariko Delgadillo Silva, Luis F. Eisenhofer, Graeme Andoniadou, Cynthia L. Bornstein, Stefan R. Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? |
| title | Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? |
| title_full | Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? |
| title_fullStr | Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? |
| title_full_unstemmed | Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? |
| title_short | Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? |
| title_sort | adrenal cortical and chromaffin stem cells: is there a common progeny related to stress adaptation? |
| topic | adrenal medulla adrenal cortex stem cells progenitors stress nestin |
| url | https://eprints.nottingham.ac.uk/42618/ https://eprints.nottingham.ac.uk/42618/ https://eprints.nottingham.ac.uk/42618/ |