Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing

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Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing

Acute myeloid leukaemia (AML) is a hierarchically structured malignancy in which aberrant leukemic stem cells drive the production of leukaemic blast cell clones. AML cells strictly depend on the bone marrow microenvironment (BMM) in which they reside. Classical AML cell cultures fail to mimic the B...

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Bibliographic Details
Main Authors:	Dhami, Sukhraj Pal S., Kappala, Shanthi S., Thompson, Alexander, Szegezdi, Eva
Format:	Article
Published:	Elsevier 2016
Online Access:	https://eprints.nottingham.ac.uk/42608/

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