A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles
Introduction It is difficult to elucidate the metabolic and regulatory factors causing lipidome perturbations. Objectives This work simplifies this process. Methods A method has been developed to query an online holistic lipid metabolic network (of 7923 metabolites) to extract the pathways t...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Springer
2017
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| Online Access: | https://eprints.nottingham.ac.uk/42506/ |
| _version_ | 1848796501778628608 |
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| author | Casbas-Pinto, Ferran Ravipati, Srinivarao Barrett, David A. Hodgman, Charlie |
| author_facet | Casbas-Pinto, Ferran Ravipati, Srinivarao Barrett, David A. Hodgman, Charlie |
| author_sort | Casbas-Pinto, Ferran |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Introduction
It is difficult to elucidate the metabolic and regulatory factors causing lipidome perturbations.
Objectives
This work simplifies this process.
Methods
A method has been developed to query an online holistic lipid metabolic network (of 7923 metabolites) to extract the pathways that connect the input list of lipids.
Results
The output enables pathway visualisation and the querying of other databases to identify potential regulators. When used to a study a plasma lipidome dataset of polycystic ovary syndrome, 14 enzymes were identified, of which 3 are linked to ELAVL1—an mRNA stabiliser.
Conclusion
This method provides a simplified approach to identifying potential regulators causing lipid-profile perturbations. |
| first_indexed | 2025-11-14T19:48:59Z |
| format | Article |
| id | nottingham-42506 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:48:59Z |
| publishDate | 2017 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-425062020-05-04T18:47:30Z https://eprints.nottingham.ac.uk/42506/ A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles Casbas-Pinto, Ferran Ravipati, Srinivarao Barrett, David A. Hodgman, Charlie Introduction It is difficult to elucidate the metabolic and regulatory factors causing lipidome perturbations. Objectives This work simplifies this process. Methods A method has been developed to query an online holistic lipid metabolic network (of 7923 metabolites) to extract the pathways that connect the input list of lipids. Results The output enables pathway visualisation and the querying of other databases to identify potential regulators. When used to a study a plasma lipidome dataset of polycystic ovary syndrome, 14 enzymes were identified, of which 3 are linked to ELAVL1—an mRNA stabiliser. Conclusion This method provides a simplified approach to identifying potential regulators causing lipid-profile perturbations. Springer 2017-05-29 Article PeerReviewed Casbas-Pinto, Ferran, Ravipati, Srinivarao, Barrett, David A. and Hodgman, Charlie (2017) A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles. Metabolomics, 13 . 81/1-81/4. ISSN 1573-3890 https://link.springer.com/article/10.1007%2Fs11306-017-1214-y doi:10.1007/s11306-017-1214-y doi:10.1007/s11306-017-1214-y |
| spellingShingle | Casbas-Pinto, Ferran Ravipati, Srinivarao Barrett, David A. Hodgman, Charlie A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles |
| title | A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles |
| title_full | A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles |
| title_fullStr | A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles |
| title_full_unstemmed | A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles |
| title_short | A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles |
| title_sort | methodology for elucidating regulatory mechanisms leading to changes in lipid profiles |
| url | https://eprints.nottingham.ac.uk/42506/ https://eprints.nottingham.ac.uk/42506/ https://eprints.nottingham.ac.uk/42506/ |