Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay
Previous in vivo electrophysiological studies suggest that the anterior cingulate cortex (ACgx) is an important substrate of novel object recognition (NOR) memory. However, intervention studies are needed to confirm this conclusion and permanent lesion studies cannot distinguish effects on encoding...
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| Format: | Article |
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Cold Spring Harbor Laboratory Press
2017
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| Online Access: | https://eprints.nottingham.ac.uk/42500/ |
| _version_ | 1848796500307476480 |
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| author | Pezze, Marie A. Marshall, Hayley J. Fone, Kevin C.F. Cassaday, Helen J. |
| author_facet | Pezze, Marie A. Marshall, Hayley J. Fone, Kevin C.F. Cassaday, Helen J. |
| author_sort | Pezze, Marie A. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Previous in vivo electrophysiological studies suggest that the anterior cingulate cortex (ACgx) is an important substrate of novel object recognition (NOR) memory. However, intervention studies are needed to confirm this conclusion and permanent lesion studies cannot distinguish effects on encoding and retrieval. The interval between encoding and retrieval tests may also be a critical determinant of the role of the ACgx. The current series of experiments used micro-infusion of the GABAA receptor agonist, muscimol, into ACgx to reversibly inactivate the area and distinguish its role in encoding and retrieval. ACgx infusions of muscimol, before encoding did not alter NOR assessed after a delay of 20 min or 24 h. However, when infused into the ACgx before retrieval muscimol impaired NOR assessed after a delay of 24 h, but not after a 20 min retention test. Together these findings suggest that the ACgx plays a time-dependent role in the retrieval, but not the encoding, of NOR memory, neuronal activation being required for the retrieval of remote (24 h old), but not recent (20 min old) visual memory. |
| first_indexed | 2025-11-14T19:48:58Z |
| format | Article |
| id | nottingham-42500 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:48:58Z |
| publishDate | 2017 |
| publisher | Cold Spring Harbor Laboratory Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-425002020-05-04T18:50:07Z https://eprints.nottingham.ac.uk/42500/ Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay Pezze, Marie A. Marshall, Hayley J. Fone, Kevin C.F. Cassaday, Helen J. Previous in vivo electrophysiological studies suggest that the anterior cingulate cortex (ACgx) is an important substrate of novel object recognition (NOR) memory. However, intervention studies are needed to confirm this conclusion and permanent lesion studies cannot distinguish effects on encoding and retrieval. The interval between encoding and retrieval tests may also be a critical determinant of the role of the ACgx. The current series of experiments used micro-infusion of the GABAA receptor agonist, muscimol, into ACgx to reversibly inactivate the area and distinguish its role in encoding and retrieval. ACgx infusions of muscimol, before encoding did not alter NOR assessed after a delay of 20 min or 24 h. However, when infused into the ACgx before retrieval muscimol impaired NOR assessed after a delay of 24 h, but not after a 20 min retention test. Together these findings suggest that the ACgx plays a time-dependent role in the retrieval, but not the encoding, of NOR memory, neuronal activation being required for the retrieval of remote (24 h old), but not recent (20 min old) visual memory. Cold Spring Harbor Laboratory Press 2017-06-15 Article PeerReviewed Pezze, Marie A., Marshall, Hayley J., Fone, Kevin C.F. and Cassaday, Helen J. (2017) Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay. Learning & Memory, 24 . pp. 310-317. ISSN 1549-5485 novel object recognition; anterior cingulate cortex; muscimol; memory retrieval; GABAA receptor http://learnmem.cshlp.org/content/24/7/310 doi:10.1101/lm.044784.116 doi:10.1101/lm.044784.116 |
| spellingShingle | novel object recognition; anterior cingulate cortex; muscimol; memory retrieval; GABAA receptor Pezze, Marie A. Marshall, Hayley J. Fone, Kevin C.F. Cassaday, Helen J. Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay |
| title | Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay |
| title_full | Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay |
| title_fullStr | Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay |
| title_full_unstemmed | Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay |
| title_short | Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay |
| title_sort | role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay |
| topic | novel object recognition; anterior cingulate cortex; muscimol; memory retrieval; GABAA receptor |
| url | https://eprints.nottingham.ac.uk/42500/ https://eprints.nottingham.ac.uk/42500/ https://eprints.nottingham.ac.uk/42500/ |