Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012
OBJECTIVES: To estimate the mortality associated with SLE during the period 1999-2012 by age, gender and region; and to ascertain the cause of death for people with SLE. METHODS: A retrospective cohort study using the UK Clinical Practice Research Datalink. Incident SLE cases diagnosed between 19...
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| Format: | Article |
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Oxford University Press
2016
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| Online Access: | https://eprints.nottingham.ac.uk/42278/ |
| _version_ | 1848796452458856448 |
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| author | Rees, Frances Doherty, Michael Grainge, Matthew J. Lanyon, Peter Davenport, Graham Zhang, Weiya |
| author_facet | Rees, Frances Doherty, Michael Grainge, Matthew J. Lanyon, Peter Davenport, Graham Zhang, Weiya |
| author_sort | Rees, Frances |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | OBJECTIVES: To estimate the mortality associated with SLE during the period 1999-2012 by age, gender and region; and to ascertain the cause of death for people with SLE.
METHODS: A retrospective cohort study using the UK Clinical Practice Research Datalink. Incident SLE cases diagnosed between 1999 and 2012 were matched by age, sex and practice to four controls. Age-, gender- and region-specific mortality rates were calculated per 1000 person-years and compared with control mortality rates using mortality rate ratios (MRRs). For individuals with linked Office of National Statistics data, cause of death was summarized by International Classification of Disease-10 chapter heading.
RESULTS: Of 2740 incident cases, 227 died, giving a mortality rate of 15.84/1000 person-years (95% CI 13.91, 18.04). This was 67% higher than in controls (MRR 1.67, 95% CI 1.43, 1.94, P < 0.001). Men with SLE had higher rates of mortality than females with SLE. Compared with controls, the mortality rate for males with SLE was 1.80 times that of male controls (95% CI 1.32, 2.45, P < 0.001); for females the mortality rate was 1.64 times higher (95% CI 1.37, 1.96, P < 0.001). The age-specific mortality rates increased significantly with age; however, the MRR diminished from 3.81 (95% CI 1.43, 10.14) in those aged <40 years to 0.82 (95% CI 0.36, 1.83) in those 90 years. There was no significant difference in mortality between regions. Circulatory system disease and malignancy were the most frequent causes of death in both cases and controls.
CONCLUSION: There remains an increased mortality for people with SLE compared with matched controls, particularly at younger ages. |
| first_indexed | 2025-11-14T19:48:12Z |
| format | Article |
| id | nottingham-42278 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:48:12Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-422782024-08-15T15:18:01Z https://eprints.nottingham.ac.uk/42278/ Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012 Rees, Frances Doherty, Michael Grainge, Matthew J. Lanyon, Peter Davenport, Graham Zhang, Weiya OBJECTIVES: To estimate the mortality associated with SLE during the period 1999-2012 by age, gender and region; and to ascertain the cause of death for people with SLE. METHODS: A retrospective cohort study using the UK Clinical Practice Research Datalink. Incident SLE cases diagnosed between 1999 and 2012 were matched by age, sex and practice to four controls. Age-, gender- and region-specific mortality rates were calculated per 1000 person-years and compared with control mortality rates using mortality rate ratios (MRRs). For individuals with linked Office of National Statistics data, cause of death was summarized by International Classification of Disease-10 chapter heading. RESULTS: Of 2740 incident cases, 227 died, giving a mortality rate of 15.84/1000 person-years (95% CI 13.91, 18.04). This was 67% higher than in controls (MRR 1.67, 95% CI 1.43, 1.94, P < 0.001). Men with SLE had higher rates of mortality than females with SLE. Compared with controls, the mortality rate for males with SLE was 1.80 times that of male controls (95% CI 1.32, 2.45, P < 0.001); for females the mortality rate was 1.64 times higher (95% CI 1.37, 1.96, P < 0.001). The age-specific mortality rates increased significantly with age; however, the MRR diminished from 3.81 (95% CI 1.43, 10.14) in those aged <40 years to 0.82 (95% CI 0.36, 1.83) in those 90 years. There was no significant difference in mortality between regions. Circulatory system disease and malignancy were the most frequent causes of death in both cases and controls. CONCLUSION: There remains an increased mortality for people with SLE compared with matched controls, particularly at younger ages. Oxford University Press 2016-01-08 Article PeerReviewed Rees, Frances, Doherty, Michael, Grainge, Matthew J., Lanyon, Peter, Davenport, Graham and Zhang, Weiya (2016) Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012. Rheumatology, 55 (5). pp. 854-860. ISSN 1462-0332 Adult Age Distribution Aged 80 and over Cause of Death Databases Factual Systemic Lupus Erythematosus Clinical Practice Research Datalink Mortality Epidemiology Female Humans Lupus Erythematosus Systemic/*mortality Male Middle Aged Retrospective Studies Sex Characteristics Sex Distribution Time Factors United Kingdom/epidemiology clinical practice research datalink epidemiology mortality systemic lupus erythematosus https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/kev424 doi:10.1093/rheumatology/kev424 doi:10.1093/rheumatology/kev424 |
| spellingShingle | Adult Age Distribution Aged 80 and over Cause of Death Databases Factual Systemic Lupus Erythematosus Clinical Practice Research Datalink Mortality Epidemiology Female Humans Lupus Erythematosus Systemic/*mortality Male Middle Aged Retrospective Studies Sex Characteristics Sex Distribution Time Factors United Kingdom/epidemiology clinical practice research datalink epidemiology mortality systemic lupus erythematosus Rees, Frances Doherty, Michael Grainge, Matthew J. Lanyon, Peter Davenport, Graham Zhang, Weiya Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012 |
| title | Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012 |
| title_full | Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012 |
| title_fullStr | Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012 |
| title_full_unstemmed | Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012 |
| title_short | Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012 |
| title_sort | mortality in systemic lupus erythematosus in the united kingdom 1999-2012 |
| topic | Adult Age Distribution Aged 80 and over Cause of Death Databases Factual Systemic Lupus Erythematosus Clinical Practice Research Datalink Mortality Epidemiology Female Humans Lupus Erythematosus Systemic/*mortality Male Middle Aged Retrospective Studies Sex Characteristics Sex Distribution Time Factors United Kingdom/epidemiology clinical practice research datalink epidemiology mortality systemic lupus erythematosus |
| url | https://eprints.nottingham.ac.uk/42278/ https://eprints.nottingham.ac.uk/42278/ https://eprints.nottingham.ac.uk/42278/ |