Transcriptional regulation and responses in filamentous fungi exposed to lignocellulose
Biofuels derived from lignocellulose are attractive alternative fuels but their production suffers from a costly and inefficient saccharification step that uses fungal enzymes. One route to improve this efficiency is to understand better the transcriptional regulation and responses of filamentous fu...
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| Format: | Book Section |
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Bentham Science
2015
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| Online Access: | https://eprints.nottingham.ac.uk/42230/ |
| _version_ | 1848796449253359616 |
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| author | Daly, Paul van Munster, Jolanda M. Archer, David B. Raulo, Roxane |
| author2 | Silva, Roberto Nascimento |
| author_facet | Silva, Roberto Nascimento Daly, Paul van Munster, Jolanda M. Archer, David B. Raulo, Roxane |
| author_sort | Daly, Paul |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Biofuels derived from lignocellulose are attractive alternative fuels but their production suffers from a costly and inefficient saccharification step that uses fungal enzymes. One route to improve this efficiency is to understand better the transcriptional regulation and responses of filamentous fungi to lignocellulose. Sensing and initial contact of the fungus with lignocellulose is an important aspect. Differences and similarities in the responses of fungi to different lignocellulosic substrates can partly be explained with existing understanding of several key regulators and their mode of action, as will be demonstrated for Trichoderma reesei, Neurospora crassa and Aspergillus spp. The regulation of genes encoding Carbohydrate Active enZymes (CAZymes) is influenced by the presence of carbohydrate monomers and short oligosaccharides, as well as the external stimuli of pH and light. We explore several important aspects of the response to lignocellulose that are not related to genes encoding CAZymes, namely the regulation of transporters, accessory proteins and stress responses. The regulation of gene expression is examined from the perspective of mixed cultures and models are presented for the nature of the transcriptional basis for any beneficial effects of such mixed cultures. Various applications in biofuel technology are based on manipulating transcriptional regulation and learning from fungal responses to lignocelluloses. Here we critically access the application of fungal transcriptional responses to industrial saccharification reactions. As part of this chapter, selected regulatory mechanisms are also explored in more detail. |
| first_indexed | 2025-11-14T19:48:09Z |
| format | Book Section |
| id | nottingham-42230 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:48:09Z |
| publishDate | 2015 |
| publisher | Bentham Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-422302020-05-04T17:09:12Z https://eprints.nottingham.ac.uk/42230/ Transcriptional regulation and responses in filamentous fungi exposed to lignocellulose Daly, Paul van Munster, Jolanda M. Archer, David B. Raulo, Roxane Biofuels derived from lignocellulose are attractive alternative fuels but their production suffers from a costly and inefficient saccharification step that uses fungal enzymes. One route to improve this efficiency is to understand better the transcriptional regulation and responses of filamentous fungi to lignocellulose. Sensing and initial contact of the fungus with lignocellulose is an important aspect. Differences and similarities in the responses of fungi to different lignocellulosic substrates can partly be explained with existing understanding of several key regulators and their mode of action, as will be demonstrated for Trichoderma reesei, Neurospora crassa and Aspergillus spp. The regulation of genes encoding Carbohydrate Active enZymes (CAZymes) is influenced by the presence of carbohydrate monomers and short oligosaccharides, as well as the external stimuli of pH and light. We explore several important aspects of the response to lignocellulose that are not related to genes encoding CAZymes, namely the regulation of transporters, accessory proteins and stress responses. The regulation of gene expression is examined from the perspective of mixed cultures and models are presented for the nature of the transcriptional basis for any beneficial effects of such mixed cultures. Various applications in biofuel technology are based on manipulating transcriptional regulation and learning from fungal responses to lignocelluloses. Here we critically access the application of fungal transcriptional responses to industrial saccharification reactions. As part of this chapter, selected regulatory mechanisms are also explored in more detail. Bentham Science Silva, Roberto Nascimento 2015-07-01 Book Section PeerReviewed Daly, Paul, van Munster, Jolanda M., Archer, David B. and Raulo, Roxane (2015) Transcriptional regulation and responses in filamentous fungi exposed to lignocellulose. In: Mycology: current and future developments: fungal biotechnology for biofuel production. Bentham Science, pp. 82-127. ISBN 9781681080741 Accessory proteins Aspergillus biofuel CAZyme gene regulation inducer light lignocellulose mixed culture model Neurospora nucleosome pH saccharification signalling stresses transcription factor transporter Trichoderma XlnR/XYR1/XLR-1 http://www.eurekaselect.com/132939/volume/1 doi:10.2174/97816810807411150101 doi:10.2174/97816810807411150101 |
| spellingShingle | Accessory proteins Aspergillus biofuel CAZyme gene regulation inducer light lignocellulose mixed culture model Neurospora nucleosome pH saccharification signalling stresses transcription factor transporter Trichoderma XlnR/XYR1/XLR-1 Daly, Paul van Munster, Jolanda M. Archer, David B. Raulo, Roxane Transcriptional regulation and responses in filamentous fungi exposed to lignocellulose |
| title | Transcriptional regulation and responses in filamentous fungi exposed to lignocellulose |
| title_full | Transcriptional regulation and responses in filamentous fungi exposed to lignocellulose |
| title_fullStr | Transcriptional regulation and responses in filamentous fungi exposed to lignocellulose |
| title_full_unstemmed | Transcriptional regulation and responses in filamentous fungi exposed to lignocellulose |
| title_short | Transcriptional regulation and responses in filamentous fungi exposed to lignocellulose |
| title_sort | transcriptional regulation and responses in filamentous fungi exposed to lignocellulose |
| topic | Accessory proteins Aspergillus biofuel CAZyme gene regulation inducer light lignocellulose mixed culture model Neurospora nucleosome pH saccharification signalling stresses transcription factor transporter Trichoderma XlnR/XYR1/XLR-1 |
| url | https://eprints.nottingham.ac.uk/42230/ https://eprints.nottingham.ac.uk/42230/ https://eprints.nottingham.ac.uk/42230/ |