Similarity- and substructure-based development of β2-adrenergic receptor ligands based on unusual scaffolds

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Similarity- and substructure-based development of β2-adrenergic receptor ligands based on unusual scaffolds

The β2-adrenergic receptor (β2AR) is a G protein-coupled receptor (GPCR) and a well-explored target. Here, we report the discovery of 13 ligands, ten of which are novel, of this particular GPCR. They have been identified by similarity- and substructure-based searches using multiple ligands, which we...

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Bibliographic Details
Main Authors:	Schmidt, Denis, Gunera, Jakub, Baker, Jillian G., Kolb, Peter
Format:	Article
Published:	American Chemical Society 2017
Subjects:	Docking; SAR-by-catalog; Similarity searches; β2-adrenergic receptor
Online Access:	https://eprints.nottingham.ac.uk/42190/

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