Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan
OBJECTIVE: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population. METHODS: Using data from the National Health Insurance (NHI) Research Database in Taiwan, we conducted a nationwide cross-sectiona...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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BMJ Publishing Group
2015
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| Online Access: | https://eprints.nottingham.ac.uk/41929/ |
| _version_ | 1848796385148665856 |
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| author | Kuo, Chang-Fu Grainge, Matthew J. See, Lai-Chu Yu, Kuang-Hui Luo, Shue-Fen Valdes, Ana M. Zhang, Weiya Doherty, Michael |
| author_facet | Kuo, Chang-Fu Grainge, Matthew J. See, Lai-Chu Yu, Kuang-Hui Luo, Shue-Fen Valdes, Ana M. Zhang, Weiya Doherty, Michael |
| author_sort | Kuo, Chang-Fu |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | OBJECTIVE: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population.
METHODS: Using data from the National Health Insurance (NHI) Research Database in Taiwan, we conducted a nationwide cross-sectional study of data collected from 22 643 748 beneficiaries of the NHI in 2004; among them 1 045 059 individuals had physician-diagnosed gout. We estimated relative risks (RR) of gout in individuals with affected first-degree and second-degree relatives and relative contributions of genes (heritability), common environment shared by family members and non-shared environment to gout susceptibility.
RESULTS: RRs for gout were significantly higher in individuals with affected first-degree relatives (men, 1.91 (95% CI 1.90 to 1.93); women, 1.97 (95% CI 1.94 to 1.99)) and also in those with affected second-degree relatives (men, 1.27 (95% CI 1.23 to 1.31); women, 1.40 (95% CI 1.35 to 1.46)). RRs (95% CIs) for individuals with an affected twin, sibling, offspring, parent, grandchild, nephew/niece, uncle/aunt and grandparent were 8.02 (6.95 to 9.26), 2.59 (2.54 to 2.63), 1.96 (1.95 to 1.97), 1.93 (1.91 to 1.94), 1.48 (1.43 to 1.53), 1.40 (1.32 to 1.47), 1.31 (1.24 to 1.39), and 1.26 (1.21 to 1.30), respectively. The relative contributions of heritability, common and non-shared environmental factors to phenotypic variance of gout were 35.1, 28.1 and 36.8% in men and 17.0, 18.5 and 64.5% in women, respectively.
CONCLUSIONS: This population-based study confirms that gout aggregates within families. The risk of gout is higher in people with a family history. Genetic and environmental factors contribute to gout aetiology, and the relative contributions are sexually dimorphic. |
| first_indexed | 2025-11-14T19:47:08Z |
| format | Article |
| id | nottingham-41929 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:47:08Z |
| publishDate | 2015 |
| publisher | BMJ Publishing Group |
| recordtype | eprints |
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| spelling | nottingham-419292020-05-04T17:01:18Z https://eprints.nottingham.ac.uk/41929/ Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan Kuo, Chang-Fu Grainge, Matthew J. See, Lai-Chu Yu, Kuang-Hui Luo, Shue-Fen Valdes, Ana M. Zhang, Weiya Doherty, Michael OBJECTIVE: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population. METHODS: Using data from the National Health Insurance (NHI) Research Database in Taiwan, we conducted a nationwide cross-sectional study of data collected from 22 643 748 beneficiaries of the NHI in 2004; among them 1 045 059 individuals had physician-diagnosed gout. We estimated relative risks (RR) of gout in individuals with affected first-degree and second-degree relatives and relative contributions of genes (heritability), common environment shared by family members and non-shared environment to gout susceptibility. RESULTS: RRs for gout were significantly higher in individuals with affected first-degree relatives (men, 1.91 (95% CI 1.90 to 1.93); women, 1.97 (95% CI 1.94 to 1.99)) and also in those with affected second-degree relatives (men, 1.27 (95% CI 1.23 to 1.31); women, 1.40 (95% CI 1.35 to 1.46)). RRs (95% CIs) for individuals with an affected twin, sibling, offspring, parent, grandchild, nephew/niece, uncle/aunt and grandparent were 8.02 (6.95 to 9.26), 2.59 (2.54 to 2.63), 1.96 (1.95 to 1.97), 1.93 (1.91 to 1.94), 1.48 (1.43 to 1.53), 1.40 (1.32 to 1.47), 1.31 (1.24 to 1.39), and 1.26 (1.21 to 1.30), respectively. The relative contributions of heritability, common and non-shared environmental factors to phenotypic variance of gout were 35.1, 28.1 and 36.8% in men and 17.0, 18.5 and 64.5% in women, respectively. CONCLUSIONS: This population-based study confirms that gout aggregates within families. The risk of gout is higher in people with a family history. Genetic and environmental factors contribute to gout aetiology, and the relative contributions are sexually dimorphic. BMJ Publishing Group 2015-01-07 Article PeerReviewed Kuo, Chang-Fu, Grainge, Matthew J., See, Lai-Chu, Yu, Kuang-Hui, Luo, Shue-Fen, Valdes, Ana M., Zhang, Weiya and Doherty, Michael (2015) Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan. Annals of the Rheumatic Diseases, 74 (2). pp. 369-374. ISSN 1468-2060 Adolescent Adult Age distribution Aged Aged 80 and over Cross-sectional studies Environment Female Genetic predisposition to disease Gout/epidemiology/genetics Humans Male Middle Aged Prevalence Sex distribution Socioeconomic factors Taiwan Young adult Arthritis Epidemiology Gout http://ard.bmj.com/content/74/2/369 doi:10.1136/annrheumdis-2013-204067 doi:10.1136/annrheumdis-2013-204067 |
| spellingShingle | Adolescent Adult Age distribution Aged Aged 80 and over Cross-sectional studies Environment Female Genetic predisposition to disease Gout/epidemiology/genetics Humans Male Middle Aged Prevalence Sex distribution Socioeconomic factors Taiwan Young adult Arthritis Epidemiology Gout Kuo, Chang-Fu Grainge, Matthew J. See, Lai-Chu Yu, Kuang-Hui Luo, Shue-Fen Valdes, Ana M. Zhang, Weiya Doherty, Michael Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan |
| title | Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan |
| title_full | Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan |
| title_fullStr | Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan |
| title_full_unstemmed | Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan |
| title_short | Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan |
| title_sort | familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in taiwan |
| topic | Adolescent Adult Age distribution Aged Aged 80 and over Cross-sectional studies Environment Female Genetic predisposition to disease Gout/epidemiology/genetics Humans Male Middle Aged Prevalence Sex distribution Socioeconomic factors Taiwan Young adult Arthritis Epidemiology Gout |
| url | https://eprints.nottingham.ac.uk/41929/ https://eprints.nottingham.ac.uk/41929/ https://eprints.nottingham.ac.uk/41929/ |