Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers
Background: Denatonium benzoate (DB) has been shown to influence ongoing ingestive behavior and gut peptide secretion. Objective: We studied how the intragastric administration of DB affects interdigestive motility, motilin and ghrelin plasma concentrations, hunger and satiety ratings, and food int...
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| Format: | Article |
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American Society for Nutrition
2017
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| Online Access: | https://eprints.nottingham.ac.uk/41906/ |
| _version_ | 1848796380317876224 |
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| author | Deloose, Eveline Janssen, Pieter Corsetti, Maura Biesiekierski, Jessica Masuy, Imke Rotondo, Alessandra Van Oudenhove, Lukas Depoortere, Inge Tack, Jan |
| author_facet | Deloose, Eveline Janssen, Pieter Corsetti, Maura Biesiekierski, Jessica Masuy, Imke Rotondo, Alessandra Van Oudenhove, Lukas Depoortere, Inge Tack, Jan |
| author_sort | Deloose, Eveline |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Denatonium benzoate (DB) has been shown to influence ongoing ingestive behavior and gut peptide secretion.
Objective: We studied how the intragastric administration of DB affects interdigestive motility, motilin and ghrelin plasma concentrations, hunger and satiety ratings, and food intake in healthy volunteers.
Design: Lingual bitter taste sensitivity was tested with the use of 6 concentrations of DB in 65 subjects. A placebo or 1 μmol DB/kg was given intragastrically to assess its effect on fasting gastrointestinal motility and hunger ratings, motilin and ghrelin plasma concentrations, satiety, and caloric intake.
Results: Women (n = 39) were more sensitive toward a lingual bitter stimulus (P = 0.005) than men (n = 26). In women (n = 10), intragastric DB switched the origin of phase III contractions from the stomach to the duodenum (P = 0.001) and decreased hunger ratings (P = 0.04). These effects were not observed in men (n = 10). In women (n = 12), motilin (P = 0.04) plasma concentrations decreased after intragastric DB administration, whereas total and octanoylated ghrelin were not affected. The intragastric administration of DB decreased hunger (P = 0.008) and increased satiety ratings (P = 0.01) after a meal (500 kcal) in 13 women without affecting gastric emptying in 6 women. Caloric intake tended to decrease after DB administration compared with the placebo (mean ± SEM: 720 ± 58 compared with 796 ± 45 kcal; P = 0.08) in 20 women.
Conclusions: Intragastric DB administration decreases both antral motility and hunger ratings during the fasting state, possibly because of a decrease in motilin release. Moreover, DB decreases hunger and increases satiety ratings after a meal and shows potential for decreasing caloric intake |
| first_indexed | 2025-11-14T19:47:04Z |
| format | Article |
| id | nottingham-41906 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:47:04Z |
| publishDate | 2017 |
| publisher | American Society for Nutrition |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-419062020-05-04T18:28:07Z https://eprints.nottingham.ac.uk/41906/ Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers Deloose, Eveline Janssen, Pieter Corsetti, Maura Biesiekierski, Jessica Masuy, Imke Rotondo, Alessandra Van Oudenhove, Lukas Depoortere, Inge Tack, Jan Background: Denatonium benzoate (DB) has been shown to influence ongoing ingestive behavior and gut peptide secretion. Objective: We studied how the intragastric administration of DB affects interdigestive motility, motilin and ghrelin plasma concentrations, hunger and satiety ratings, and food intake in healthy volunteers. Design: Lingual bitter taste sensitivity was tested with the use of 6 concentrations of DB in 65 subjects. A placebo or 1 μmol DB/kg was given intragastrically to assess its effect on fasting gastrointestinal motility and hunger ratings, motilin and ghrelin plasma concentrations, satiety, and caloric intake. Results: Women (n = 39) were more sensitive toward a lingual bitter stimulus (P = 0.005) than men (n = 26). In women (n = 10), intragastric DB switched the origin of phase III contractions from the stomach to the duodenum (P = 0.001) and decreased hunger ratings (P = 0.04). These effects were not observed in men (n = 10). In women (n = 12), motilin (P = 0.04) plasma concentrations decreased after intragastric DB administration, whereas total and octanoylated ghrelin were not affected. The intragastric administration of DB decreased hunger (P = 0.008) and increased satiety ratings (P = 0.01) after a meal (500 kcal) in 13 women without affecting gastric emptying in 6 women. Caloric intake tended to decrease after DB administration compared with the placebo (mean ± SEM: 720 ± 58 compared with 796 ± 45 kcal; P = 0.08) in 20 women. Conclusions: Intragastric DB administration decreases both antral motility and hunger ratings during the fasting state, possibly because of a decrease in motilin release. Moreover, DB decreases hunger and increases satiety ratings after a meal and shows potential for decreasing caloric intake American Society for Nutrition 2017-02-01 Article PeerReviewed Deloose, Eveline, Janssen, Pieter, Corsetti, Maura, Biesiekierski, Jessica, Masuy, Imke, Rotondo, Alessandra, Van Oudenhove, Lukas, Depoortere, Inge and Tack, Jan (2017) Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers. American Journal of Clinical Nutrition . ISSN 1938-3207 Bitter hunger migrating motor complex motilin denatonium benzoate http://ajcn.nutrition.org/content/early/2017/02/01/ajcn.116.138297.abstract doi:10.3945/ajcn.116.138297 doi:10.3945/ajcn.116.138297 |
| spellingShingle | Bitter hunger migrating motor complex motilin denatonium benzoate Deloose, Eveline Janssen, Pieter Corsetti, Maura Biesiekierski, Jessica Masuy, Imke Rotondo, Alessandra Van Oudenhove, Lukas Depoortere, Inge Tack, Jan Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers |
| title | Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers |
| title_full | Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers |
| title_fullStr | Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers |
| title_full_unstemmed | Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers |
| title_short | Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers |
| title_sort | intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers |
| topic | Bitter hunger migrating motor complex motilin denatonium benzoate |
| url | https://eprints.nottingham.ac.uk/41906/ https://eprints.nottingham.ac.uk/41906/ https://eprints.nottingham.ac.uk/41906/ |