Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry
Background: Only few studies have applied high-resolution manometry (HRM) to the study of colonic motility in adults and none of them have concurrently evaluated colonic and anal motor activity. Aims: To evaluate colonic and anal motor activity by means of HRM in healthy subjects. As the present stu...
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Nature Publishing Group
2017
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| Online Access: | https://eprints.nottingham.ac.uk/41900/ |
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| author | Corsetti, Maura Pagliaro, Giuseppe Demedts, Ingrid Deloose, Eveline Gevers, Annemie Scheerens, Charlotte Rommel, Nathalie Tack, Jan |
| author_facet | Corsetti, Maura Pagliaro, Giuseppe Demedts, Ingrid Deloose, Eveline Gevers, Annemie Scheerens, Charlotte Rommel, Nathalie Tack, Jan |
| author_sort | Corsetti, Maura |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Only few studies have applied high-resolution manometry (HRM) to the study of colonic motility in adults and none of them have concurrently evaluated colonic and anal motor activity. Aims: To evaluate colonic and anal motor activity by means of HRM in healthy subjects. As the present study revealed the presence of a new colonic motor pattern (pan-colonic pressurizations) in healthy subjects, three additional studies were conducted: the first and the second to exclude that this motor event results from an artefact due to abdominal wall contraction and to confirm its modulation by cholinergic stimulation and the third, as pilot study, to test the hypothesis that this colonic pattern is defective in patients with chronic constipation refractory to current pharmacological treatments. Methods: In both volunteers and patients the HRM catheter was advanced proximally during colonoscopy. Results: In all subjects, pressure increases of 15±3 mmHg and 24±4s simultaneously occurring in all colonic sensors (pan-colonic pressurizations), associated with anal sphincter relaxation were identified. Subjects had 85±38 pan-colonic pressurizations which increased significantly during meal (p=0.007) and decreased afterward (p=0.01), and were correlated with feelings of and desire to evacuate gas. The mean number of propagating sequences was 47±39, and only retrograde increased significantly postprandially (p=0.01). Pan-colonic pressurizations differed from strain artifacts and significantly increased after prostigmine. In patients pan-colonic pressurizations were significantly reduced as compared to volunteers. Conclusions: Pan-colonic pressurizations associated with relaxations of the anal sphincter represent a new colonic motor pattern which seems to be defective in patients with treatment-refractory chronic constipation and may play a role in the transport of colonic gas and in the facilitation of the propagating sequences-induced colonic transport. |
| first_indexed | 2025-11-14T19:47:02Z |
| format | Article |
| id | nottingham-41900 |
| institution | University of Nottingham Malaysia Campus |
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| last_indexed | 2025-11-14T19:47:02Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-419002020-05-04T18:39:38Z https://eprints.nottingham.ac.uk/41900/ Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry Corsetti, Maura Pagliaro, Giuseppe Demedts, Ingrid Deloose, Eveline Gevers, Annemie Scheerens, Charlotte Rommel, Nathalie Tack, Jan Background: Only few studies have applied high-resolution manometry (HRM) to the study of colonic motility in adults and none of them have concurrently evaluated colonic and anal motor activity. Aims: To evaluate colonic and anal motor activity by means of HRM in healthy subjects. As the present study revealed the presence of a new colonic motor pattern (pan-colonic pressurizations) in healthy subjects, three additional studies were conducted: the first and the second to exclude that this motor event results from an artefact due to abdominal wall contraction and to confirm its modulation by cholinergic stimulation and the third, as pilot study, to test the hypothesis that this colonic pattern is defective in patients with chronic constipation refractory to current pharmacological treatments. Methods: In both volunteers and patients the HRM catheter was advanced proximally during colonoscopy. Results: In all subjects, pressure increases of 15±3 mmHg and 24±4s simultaneously occurring in all colonic sensors (pan-colonic pressurizations), associated with anal sphincter relaxation were identified. Subjects had 85±38 pan-colonic pressurizations which increased significantly during meal (p=0.007) and decreased afterward (p=0.01), and were correlated with feelings of and desire to evacuate gas. The mean number of propagating sequences was 47±39, and only retrograde increased significantly postprandially (p=0.01). Pan-colonic pressurizations differed from strain artifacts and significantly increased after prostigmine. In patients pan-colonic pressurizations were significantly reduced as compared to volunteers. Conclusions: Pan-colonic pressurizations associated with relaxations of the anal sphincter represent a new colonic motor pattern which seems to be defective in patients with treatment-refractory chronic constipation and may play a role in the transport of colonic gas and in the facilitation of the propagating sequences-induced colonic transport. Nature Publishing Group 2017-03-31 Article PeerReviewed Corsetti, Maura, Pagliaro, Giuseppe, Demedts, Ingrid, Deloose, Eveline, Gevers, Annemie, Scheerens, Charlotte, Rommel, Nathalie and Tack, Jan (2017) Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry. American Journal of Gastroenterology, 112 (3). pp. 479-489. ISSN 1572-0241 pan-colonic pressurizations colonic motility anal relaxation high-resolution manometry. https://www.nature.com/ajg/journal/v112/n3/full/ajg2016341a.html doi:10.1038/ajg.2016.341 doi:10.1038/ajg.2016.341 |
| spellingShingle | pan-colonic pressurizations colonic motility anal relaxation high-resolution manometry. Corsetti, Maura Pagliaro, Giuseppe Demedts, Ingrid Deloose, Eveline Gevers, Annemie Scheerens, Charlotte Rommel, Nathalie Tack, Jan Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry |
| title | Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry |
| title_full | Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry |
| title_fullStr | Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry |
| title_full_unstemmed | Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry |
| title_short | Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry |
| title_sort | pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry |
| topic | pan-colonic pressurizations colonic motility anal relaxation high-resolution manometry. |
| url | https://eprints.nottingham.ac.uk/41900/ https://eprints.nottingham.ac.uk/41900/ https://eprints.nottingham.ac.uk/41900/ |