Psychosocial stress and brain function in adolescent psychopathology
Objective: To explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships. Method: Participants were community adolescents recruited as part of the...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
American Psychiatric Publishing
2017
|
| Online Access: | https://eprints.nottingham.ac.uk/41791/ |
| _version_ | 1848796355024125952 |
|---|---|
| author | Quinlan, Erin Burke Cattrell, Anna Jia, Tianye Artiges, Eric Banaschewski, Tobias Barker, Gareth Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Brühl, Rüdiger Conrod, Patricia J. Desrivières, Sylvane Flor, Herta Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny A. Heinz, Andreas Nees, Frauke Paillère-Martinot, Marie-Laure Papadopoulos-Orfanos, Dimitri Paus, Tomáš Poustka, Luise Smolka, Michael N. Vetter, Nora C. Walter, Henrik Whelan, Robert Buitelaar, Jan K. Happé, Francesca Loth, Eva Barker, Edward D. Schumann, Gunter |
| author_facet | Quinlan, Erin Burke Cattrell, Anna Jia, Tianye Artiges, Eric Banaschewski, Tobias Barker, Gareth Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Brühl, Rüdiger Conrod, Patricia J. Desrivières, Sylvane Flor, Herta Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny A. Heinz, Andreas Nees, Frauke Paillère-Martinot, Marie-Laure Papadopoulos-Orfanos, Dimitri Paus, Tomáš Poustka, Luise Smolka, Michael N. Vetter, Nora C. Walter, Henrik Whelan, Robert Buitelaar, Jan K. Happé, Francesca Loth, Eva Barker, Edward D. Schumann, Gunter |
| author_sort | Quinlan, Erin Burke |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objective: To explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships.
Method: Participants were community adolescents recruited as part of the European IMAGEN study. Bilateral amygdala regions of interest were used to assess the relationship between the three symptom domains with fMRI neural reactivity during passive viewing of dynamic angry and neutral facial expressions. Exploratory functional connectivity and whole-brain multiple regression approaches were used to analyze how the symptoms and psychosocial stress relate to other brain regions.
Results: In response to the social-emotional stimuli, adolescents with high levels of conduct or hyperactivity/inattention symptoms showed hyperactivity of the amygdala, and several regions across the brain, when they experienced a greater number of stressful life events. This effect was not observed with emotional symptoms. A cluster in the mid-cingulate was found to be common to both conduct problems and hyperactivity symptoms. Exploratory functional connectivity analyses suggested amygdala-precuneus connectivity is associated with hyperactivity/inattention symptoms.
Conclusions: The results link hyperactive amygdala responses, and regions critical for top-down emotional processing, with high levels of psychosocial stress in individuals with greater conduct and hyperactivity/inattention symptoms. This work highlights the importance of studying how psychosocial stress impacts functional brain responses to social-emotional stimuli, particularly in adolescents with externalizing symptoms. |
| first_indexed | 2025-11-14T19:46:39Z |
| format | Article |
| id | nottingham-41791 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:46:39Z |
| publishDate | 2017 |
| publisher | American Psychiatric Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-417912020-05-04T18:58:43Z https://eprints.nottingham.ac.uk/41791/ Psychosocial stress and brain function in adolescent psychopathology Quinlan, Erin Burke Cattrell, Anna Jia, Tianye Artiges, Eric Banaschewski, Tobias Barker, Gareth Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Brühl, Rüdiger Conrod, Patricia J. Desrivières, Sylvane Flor, Herta Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny A. Heinz, Andreas Nees, Frauke Paillère-Martinot, Marie-Laure Papadopoulos-Orfanos, Dimitri Paus, Tomáš Poustka, Luise Smolka, Michael N. Vetter, Nora C. Walter, Henrik Whelan, Robert Buitelaar, Jan K. Happé, Francesca Loth, Eva Barker, Edward D. Schumann, Gunter Objective: To explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships. Method: Participants were community adolescents recruited as part of the European IMAGEN study. Bilateral amygdala regions of interest were used to assess the relationship between the three symptom domains with fMRI neural reactivity during passive viewing of dynamic angry and neutral facial expressions. Exploratory functional connectivity and whole-brain multiple regression approaches were used to analyze how the symptoms and psychosocial stress relate to other brain regions. Results: In response to the social-emotional stimuli, adolescents with high levels of conduct or hyperactivity/inattention symptoms showed hyperactivity of the amygdala, and several regions across the brain, when they experienced a greater number of stressful life events. This effect was not observed with emotional symptoms. A cluster in the mid-cingulate was found to be common to both conduct problems and hyperactivity symptoms. Exploratory functional connectivity analyses suggested amygdala-precuneus connectivity is associated with hyperactivity/inattention symptoms. Conclusions: The results link hyperactive amygdala responses, and regions critical for top-down emotional processing, with high levels of psychosocial stress in individuals with greater conduct and hyperactivity/inattention symptoms. This work highlights the importance of studying how psychosocial stress impacts functional brain responses to social-emotional stimuli, particularly in adolescents with externalizing symptoms. American Psychiatric Publishing 2017-08-01 Article PeerReviewed Quinlan, Erin Burke, Cattrell, Anna, Jia, Tianye, Artiges, Eric, Banaschewski, Tobias, Barker, Gareth, Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Brühl, Rüdiger, Conrod, Patricia J., Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny A., Heinz, Andreas, Nees, Frauke, Paillère-Martinot, Marie-Laure, Papadopoulos-Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Vetter, Nora C., Walter, Henrik, Whelan, Robert, Buitelaar, Jan K., Happé, Francesca, Loth, Eva, Barker, Edward D. and Schumann, Gunter (2017) Psychosocial stress and brain function in adolescent psychopathology. American Journal of Psychiatry, 174 (8). pp. 785-794. ISSN 1535-7228 http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2017.16040464 doi:10.1176/appi.ajp.2017.16040464 doi:10.1176/appi.ajp.2017.16040464 |
| spellingShingle | Quinlan, Erin Burke Cattrell, Anna Jia, Tianye Artiges, Eric Banaschewski, Tobias Barker, Gareth Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Brühl, Rüdiger Conrod, Patricia J. Desrivières, Sylvane Flor, Herta Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny A. Heinz, Andreas Nees, Frauke Paillère-Martinot, Marie-Laure Papadopoulos-Orfanos, Dimitri Paus, Tomáš Poustka, Luise Smolka, Michael N. Vetter, Nora C. Walter, Henrik Whelan, Robert Buitelaar, Jan K. Happé, Francesca Loth, Eva Barker, Edward D. Schumann, Gunter Psychosocial stress and brain function in adolescent psychopathology |
| title | Psychosocial stress and brain function in adolescent psychopathology |
| title_full | Psychosocial stress and brain function in adolescent psychopathology |
| title_fullStr | Psychosocial stress and brain function in adolescent psychopathology |
| title_full_unstemmed | Psychosocial stress and brain function in adolescent psychopathology |
| title_short | Psychosocial stress and brain function in adolescent psychopathology |
| title_sort | psychosocial stress and brain function in adolescent psychopathology |
| url | https://eprints.nottingham.ac.uk/41791/ https://eprints.nottingham.ac.uk/41791/ https://eprints.nottingham.ac.uk/41791/ |