Protein–like fully reversible tetramerisation and super-association of an aminocellulose
Unusual protein-like, partially reversible associative behaviour has recently been observed in solutions of the water soluble carbohydrates known as 6-deoxy-6-(v-aminoalkyl)aminocelluloses, which produce controllable self-assembling films for enzyme immobilisation and other biotechnological applicat...
| Main Authors: | , , , , , , |
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| Format: | Article |
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Nature Publishing Group
2014
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| Online Access: | https://eprints.nottingham.ac.uk/41748/ |
| _version_ | 1848796344737595392 |
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| author | Nikolajski, Melanie Adams, Gary G. Gillis, Richard B. Besong, David Tabot Rowe, Arthur J. Heinze, Thomas Harding, Stephen E. |
| author_facet | Nikolajski, Melanie Adams, Gary G. Gillis, Richard B. Besong, David Tabot Rowe, Arthur J. Heinze, Thomas Harding, Stephen E. |
| author_sort | Nikolajski, Melanie |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Unusual protein-like, partially reversible associative behaviour has recently been observed in solutions of the water soluble carbohydrates known as 6-deoxy-6-(v-aminoalkyl)aminocelluloses, which produce controllable self-assembling films for enzyme immobilisation and other biotechnological applications. Now, for the first time, we have found a fully reversible self-association (tetramerisation) within this family of polysaccharides. Remarkably these carbohydrate tetramers are then seen to associate further in a regular way into supra-molecular complexes. Fully reversible oligomerisation has been hitherto completely unknown for carbohydrates and instead resembles in some respects the assembly of polypeptides and proteins like haemoglobin and its sickle cell mutation. Our traditional perceptions as to what might be considered ‘‘protein-like’’ and what might be considered as ‘‘carbohydrate-like’’ behaviour may need to be rendered more flexible, at least as far as interaction phenomena are concerned. |
| first_indexed | 2025-11-14T19:46:30Z |
| format | Article |
| id | nottingham-41748 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:46:30Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-417482020-05-04T16:41:19Z https://eprints.nottingham.ac.uk/41748/ Protein–like fully reversible tetramerisation and super-association of an aminocellulose Nikolajski, Melanie Adams, Gary G. Gillis, Richard B. Besong, David Tabot Rowe, Arthur J. Heinze, Thomas Harding, Stephen E. Unusual protein-like, partially reversible associative behaviour has recently been observed in solutions of the water soluble carbohydrates known as 6-deoxy-6-(v-aminoalkyl)aminocelluloses, which produce controllable self-assembling films for enzyme immobilisation and other biotechnological applications. Now, for the first time, we have found a fully reversible self-association (tetramerisation) within this family of polysaccharides. Remarkably these carbohydrate tetramers are then seen to associate further in a regular way into supra-molecular complexes. Fully reversible oligomerisation has been hitherto completely unknown for carbohydrates and instead resembles in some respects the assembly of polypeptides and proteins like haemoglobin and its sickle cell mutation. Our traditional perceptions as to what might be considered ‘‘protein-like’’ and what might be considered as ‘‘carbohydrate-like’’ behaviour may need to be rendered more flexible, at least as far as interaction phenomena are concerned. Nature Publishing Group 2014-01-24 Article PeerReviewed Nikolajski, Melanie, Adams, Gary G., Gillis, Richard B., Besong, David Tabot, Rowe, Arthur J., Heinze, Thomas and Harding, Stephen E. (2014) Protein–like fully reversible tetramerisation and super-association of an aminocellulose. Scientific Reports, 4 . 3861/1-3861/5. ISSN 2045-2322 https://doi.org/10.1038/srep03861 doi:10.1038/srep03861 doi:10.1038/srep03861 |
| spellingShingle | Nikolajski, Melanie Adams, Gary G. Gillis, Richard B. Besong, David Tabot Rowe, Arthur J. Heinze, Thomas Harding, Stephen E. Protein–like fully reversible tetramerisation and super-association of an aminocellulose |
| title | Protein–like fully reversible tetramerisation and super-association of an aminocellulose |
| title_full | Protein–like fully reversible tetramerisation and super-association of an aminocellulose |
| title_fullStr | Protein–like fully reversible tetramerisation and super-association of an aminocellulose |
| title_full_unstemmed | Protein–like fully reversible tetramerisation and super-association of an aminocellulose |
| title_short | Protein–like fully reversible tetramerisation and super-association of an aminocellulose |
| title_sort | protein–like fully reversible tetramerisation and super-association of an aminocellulose |
| url | https://eprints.nottingham.ac.uk/41748/ https://eprints.nottingham.ac.uk/41748/ https://eprints.nottingham.ac.uk/41748/ |