How to screen for non-adherence to antihypertensive therapy
The quality of assessment of non-adherence to treatment in hypertensive is poor. Within this review, we discuss the different methods used to assess adherence to blood-pressure-lowering medications in hypertension patients. Subjective reports such as physicians’ perceptions are inaccurate, and quest...
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| Format: | Article |
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Springer
2016
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| Online Access: | https://eprints.nottingham.ac.uk/41694/ |
| _version_ | 1848796333061701632 |
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| author | Gupta, Pankaj Patel, Prashanth Horne, Robert Buchanan, Heather Williams, Bryan Tomaszewski, Maciej |
| author_facet | Gupta, Pankaj Patel, Prashanth Horne, Robert Buchanan, Heather Williams, Bryan Tomaszewski, Maciej |
| author_sort | Gupta, Pankaj |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The quality of assessment of non-adherence to treatment in hypertensive is poor. Within this review, we discuss the different methods used to assess adherence to blood-pressure-lowering medications in hypertension patients. Subjective reports such as physicians’ perceptions are inaccurate, and questionnaires completed by patients tend to overreport adherence and show a low diagnostic specificity. Indirect objective methods such as pharmacy database records can be useful, but they are limited by the robustness of the recorded data. Electronic medication monitoring devices are accurate but usually track adherence to only a single medication and can be expensive. Overall, the fundamental issue with indirect objective measures is that they do not fully confirm ingestion of antihypertensive medications. Detection of antihypertensive medications in body fluids using liquid chromatography–tandem mass spectrometry is currently, in our view, the most robust and clinically useful method to assess non-adherence to blood-pressure-lowering treatment. It is particularly helpful in patients presenting with resistant, refractory or uncontrolled hypertension despite the optimal therapy. We recommend using this diagnostic strategy to detect non-adherence alongside a no-blame approach tailoring support to address the perceptions (e.g. beliefs about the illness and treatment) and practicalities (e.g. capability and resources) influencing motivation and ability to adhere. |
| first_indexed | 2025-11-14T19:46:19Z |
| format | Article |
| id | nottingham-41694 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:46:19Z |
| publishDate | 2016 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-416942020-05-04T18:19:54Z https://eprints.nottingham.ac.uk/41694/ How to screen for non-adherence to antihypertensive therapy Gupta, Pankaj Patel, Prashanth Horne, Robert Buchanan, Heather Williams, Bryan Tomaszewski, Maciej The quality of assessment of non-adherence to treatment in hypertensive is poor. Within this review, we discuss the different methods used to assess adherence to blood-pressure-lowering medications in hypertension patients. Subjective reports such as physicians’ perceptions are inaccurate, and questionnaires completed by patients tend to overreport adherence and show a low diagnostic specificity. Indirect objective methods such as pharmacy database records can be useful, but they are limited by the robustness of the recorded data. Electronic medication monitoring devices are accurate but usually track adherence to only a single medication and can be expensive. Overall, the fundamental issue with indirect objective measures is that they do not fully confirm ingestion of antihypertensive medications. Detection of antihypertensive medications in body fluids using liquid chromatography–tandem mass spectrometry is currently, in our view, the most robust and clinically useful method to assess non-adherence to blood-pressure-lowering treatment. It is particularly helpful in patients presenting with resistant, refractory or uncontrolled hypertension despite the optimal therapy. We recommend using this diagnostic strategy to detect non-adherence alongside a no-blame approach tailoring support to address the perceptions (e.g. beliefs about the illness and treatment) and practicalities (e.g. capability and resources) influencing motivation and ability to adhere. Springer 2016-11-26 Article PeerReviewed Gupta, Pankaj, Patel, Prashanth, Horne, Robert, Buchanan, Heather, Williams, Bryan and Tomaszewski, Maciej (2016) How to screen for non-adherence to antihypertensive therapy. Current Hypertension Reports, 18 (12). 88/1-88/8. ISSN 1534-3111 Hypertension Uncontrolled hypertension Non-adherence Blood pressure medication https://link.springer.com/article/10.1007%2Fs11906-016-0697-7 doi:10.1007/s11906-016-0697-7 doi:10.1007/s11906-016-0697-7 |
| spellingShingle | Hypertension Uncontrolled hypertension Non-adherence Blood pressure medication Gupta, Pankaj Patel, Prashanth Horne, Robert Buchanan, Heather Williams, Bryan Tomaszewski, Maciej How to screen for non-adherence to antihypertensive therapy |
| title | How to screen for non-adherence to antihypertensive therapy |
| title_full | How to screen for non-adherence to antihypertensive therapy |
| title_fullStr | How to screen for non-adherence to antihypertensive therapy |
| title_full_unstemmed | How to screen for non-adherence to antihypertensive therapy |
| title_short | How to screen for non-adherence to antihypertensive therapy |
| title_sort | how to screen for non-adherence to antihypertensive therapy |
| topic | Hypertension Uncontrolled hypertension Non-adherence Blood pressure medication |
| url | https://eprints.nottingham.ac.uk/41694/ https://eprints.nottingham.ac.uk/41694/ https://eprints.nottingham.ac.uk/41694/ |