IL-36α induces maturation of Th1-inducing human MDDC and synergises with IFN-γ to induce high surface expression of CD14 and CD11c

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IL-36α induces maturation of Th1-inducing human MDDC and synergises with IFN-γ to induce high surface expression of CD14 and CD11c

We show that IL-36α induced maturation of human MDDCs and stimulated differentiation of IFN-γ producing (Type 1) CD3+ lymphocytes but was not as effective as IL-36β in doing so. For the first time, we also show that IL-36α induced expression of CD14 by MDDCs and this was highly potentiated by co-cul...

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Bibliographic Details
Main Authors:	Higgins, John, Mutamba, Shilla, Mahida, Yashwant R., Barrow, Paul, Foster, Neil
Format:	Article
Published:	Elsevier 2015
Subjects:	Dendritic cell; IL-36R; IL-36α; IFN-γ; CD209
Online Access:	https://eprints.nottingham.ac.uk/41588/

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