Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs
We show that oral inoculation of 14 day old conventional piglets with a rough attenuated Salmonella enterica serovar Infantis 1326/28Фr (serogroup C1), 24 h prior to oral challenge with S. enterica serovar Typhimurium 4/74 (serogroup B), resulted in significant weight gain (~ 10%) measured at 14 day...
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/41586/ |
| _version_ | 1848796308986396672 |
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| author | Foster, Neil Richards, Luke Higgins, John Kanellos, Theo Barrow, Paul |
| author_facet | Foster, Neil Richards, Luke Higgins, John Kanellos, Theo Barrow, Paul |
| author_sort | Foster, Neil |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We show that oral inoculation of 14 day old conventional piglets with a rough attenuated Salmonella enterica serovar Infantis 1326/28Фr (serogroup C1), 24 h prior to oral challenge with S. enterica serovar Typhimurium 4/74 (serogroup B), resulted in significant weight gain (~ 10%) measured at 14 days post-weaning (38 days of age). Two days after challenge the S. Typhimurium induced stunting and, in some cases loss, of villi but this was prevented by pre-inoculation with the S. Infantis strain. The clinical signs of disease associated with S. Typhimurium 4/74 challenge and faecal shedding were also significantly (P < 0.05) reduced by pre-inoculation with the S. Infantis mutant. Pre-inoculation of pigs with the S. Infantis mutant also increased weight gain in pigs challenged with pathogenic Escherichia coli. However, Mycobacterium bovis BCG, an unrelated intracellular bacterium, did not protect against challenge with S. Typhimurium 4/74. |
| first_indexed | 2025-11-14T19:45:56Z |
| format | Article |
| id | nottingham-41586 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:45:56Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-415862020-05-04T17:35:04Z https://eprints.nottingham.ac.uk/41586/ Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs Foster, Neil Richards, Luke Higgins, John Kanellos, Theo Barrow, Paul We show that oral inoculation of 14 day old conventional piglets with a rough attenuated Salmonella enterica serovar Infantis 1326/28Фr (serogroup C1), 24 h prior to oral challenge with S. enterica serovar Typhimurium 4/74 (serogroup B), resulted in significant weight gain (~ 10%) measured at 14 days post-weaning (38 days of age). Two days after challenge the S. Typhimurium induced stunting and, in some cases loss, of villi but this was prevented by pre-inoculation with the S. Infantis strain. The clinical signs of disease associated with S. Typhimurium 4/74 challenge and faecal shedding were also significantly (P < 0.05) reduced by pre-inoculation with the S. Infantis mutant. Pre-inoculation of pigs with the S. Infantis mutant also increased weight gain in pigs challenged with pathogenic Escherichia coli. However, Mycobacterium bovis BCG, an unrelated intracellular bacterium, did not protect against challenge with S. Typhimurium 4/74. Elsevier 2016-02-28 Article PeerReviewed Foster, Neil, Richards, Luke, Higgins, John, Kanellos, Theo and Barrow, Paul (2016) Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs. Research in Veterinary Science, 104 . pp. 152-159. ISSN 1532-2661 Salmonella; Pigs; Serogroup; Vaccine; Innate immunity; Weight gain https://doi.org/10.1016/j.rvsc.2015.12.013 doi:10.1016/j.rvsc.2015.12.013 doi:10.1016/j.rvsc.2015.12.013 |
| spellingShingle | Salmonella; Pigs; Serogroup; Vaccine; Innate immunity; Weight gain Foster, Neil Richards, Luke Higgins, John Kanellos, Theo Barrow, Paul Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs |
| title | Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs |
| title_full | Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs |
| title_fullStr | Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs |
| title_full_unstemmed | Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs |
| title_short | Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs |
| title_sort | oral vaccination with a rough attenuated mutant of s. infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in s. typhimurium challenged pigs |
| topic | Salmonella; Pigs; Serogroup; Vaccine; Innate immunity; Weight gain |
| url | https://eprints.nottingham.ac.uk/41586/ https://eprints.nottingham.ac.uk/41586/ https://eprints.nottingham.ac.uk/41586/ |