IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation

IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation

We show that IL-36R is expressed by T (CD4+ and CD8+) and B (CD19+) lymphocytes in human blood and also by CD4+ T lymphocytes in the intestinal lamina propria. IL-36R protein was mostly stored in the cytoplasm of CD4 lymphocytes and B cells, during steady state conditions and the greatest expression...

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Bibliographic Details
Main Authors: Penha, Rafael, Higgins, John, Mutamba, Shilla, Barrow, Paul, Mahida, Yashwant R., Foster, Neil
Format: Article
Published: Elsevier 2016
Subjects:
IL-36; IL-36R; Human; Lymphocyte
Online Access:https://eprints.nottingham.ac.uk/41582/

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