Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor
Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coilin...
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| Format: | Article |
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Royal Society of Chemistry
2017
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| Online Access: | https://eprints.nottingham.ac.uk/41547/ |
| _version_ | 1848796299980177408 |
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| author | Limón, David Jiménez-Newman, Claire Calpena, Ana C. Gonzalez-Campo, Arántzazu Amabilino, David A. Pérez-García, Lluïsa |
| author_facet | Limón, David Jiménez-Newman, Claire Calpena, Ana C. Gonzalez-Campo, Arántzazu Amabilino, David A. Pérez-García, Lluïsa |
| author_sort | Limón, David |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration. |
| first_indexed | 2025-11-14T19:45:47Z |
| format | Article |
| id | nottingham-41547 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:45:47Z |
| publishDate | 2017 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-415472020-05-04T18:38:45Z https://eprints.nottingham.ac.uk/41547/ Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor Limón, David Jiménez-Newman, Claire Calpena, Ana C. Gonzalez-Campo, Arántzazu Amabilino, David A. Pérez-García, Lluïsa Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration. Royal Society of Chemistry 2017-03-22 Article PeerReviewed Limón, David, Jiménez-Newman, Claire, Calpena, Ana C., Gonzalez-Campo, Arántzazu, Amabilino, David A. and Pérez-García, Lluïsa (2017) Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor. Chemical Communications, 53 . pp. 1433-1434. ISSN 1364-548X http://pubs.rsc.org/en/Content/ArticleLanding/2017/CC/C6CC09392B#!divAbstract doi:10.1039/C6CC09392B doi:10.1039/C6CC09392B |
| spellingShingle | Limón, David Jiménez-Newman, Claire Calpena, Ana C. Gonzalez-Campo, Arántzazu Amabilino, David A. Pérez-García, Lluïsa Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor |
| title | Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor |
| title_full | Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor |
| title_fullStr | Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor |
| title_full_unstemmed | Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor |
| title_short | Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor |
| title_sort | microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor |
| url | https://eprints.nottingham.ac.uk/41547/ https://eprints.nottingham.ac.uk/41547/ https://eprints.nottingham.ac.uk/41547/ |