Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model
Steroidogenic tissues such as the ovary, testes or adrenal glands are paradoxical in that they often indicate actions of steroid hormones within a dynamic range of ligand concentration in a high nanomolar or even micromolar level, i.e. at the natural concentrations existing within those organs. Yet...
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Elsevier
2014
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| Online Access: | https://eprints.nottingham.ac.uk/41439/ |
| _version_ | 1848796273401921536 |
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| author | Ivell, Richard Dai, Yanzhenzi Mann, Navdeep Anand-Ivell, Ravinder |
| author_facet | Ivell, Richard Dai, Yanzhenzi Mann, Navdeep Anand-Ivell, Ravinder |
| author_sort | Ivell, Richard |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Steroidogenic tissues such as the ovary, testes or adrenal glands are paradoxical in that they often indicate actions of steroid hormones within a dynamic range of ligand concentration in a high nanomolar or even micromolar level, i.e. at the natural concentrations existing within those organs. Yet ligand-activated nuclear steroid receptors act classically by direct interaction with DNA in the picomolar or low nanomolar range. Moreover, global genomic studies suggest that less than 40% of steroid-regulated genes involve classical responsive elements in gene promoter regions. The bovine oxytocin gene is a key element in the maternal recognition of pregnancy in ruminants and is regulated via an SF1 site in its proximal promoter. This gene is also regulated by steroids acting in a non-classical manner, involving nuclear receptors which do not interact directly with DNA. Dose-response relationships for these actions are in the high nanomolar range. Similar ‘steroid sensing’ mechanisms may prevail for other SF1-regulated genes and predict alternative pathways by which environmental endocrine disruptors might influence the functioning of steroid-producing organs and hence indirectly the steroid-dependent control of physiology and development. |
| first_indexed | 2025-11-14T19:45:22Z |
| format | Article |
| id | nottingham-41439 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:45:22Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-414392020-05-04T16:41:18Z https://eprints.nottingham.ac.uk/41439/ Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model Ivell, Richard Dai, Yanzhenzi Mann, Navdeep Anand-Ivell, Ravinder Steroidogenic tissues such as the ovary, testes or adrenal glands are paradoxical in that they often indicate actions of steroid hormones within a dynamic range of ligand concentration in a high nanomolar or even micromolar level, i.e. at the natural concentrations existing within those organs. Yet ligand-activated nuclear steroid receptors act classically by direct interaction with DNA in the picomolar or low nanomolar range. Moreover, global genomic studies suggest that less than 40% of steroid-regulated genes involve classical responsive elements in gene promoter regions. The bovine oxytocin gene is a key element in the maternal recognition of pregnancy in ruminants and is regulated via an SF1 site in its proximal promoter. This gene is also regulated by steroids acting in a non-classical manner, involving nuclear receptors which do not interact directly with DNA. Dose-response relationships for these actions are in the high nanomolar range. Similar ‘steroid sensing’ mechanisms may prevail for other SF1-regulated genes and predict alternative pathways by which environmental endocrine disruptors might influence the functioning of steroid-producing organs and hence indirectly the steroid-dependent control of physiology and development. Elsevier 2014-01-25 Article PeerReviewed Ivell, Richard, Dai, Yanzhenzi, Mann, Navdeep and Anand-Ivell, Ravinder (2014) Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model. Molecular and Cellular Endocrinology, 382 (1). pp. 466-471. ISSN 1872-8057 Oxytocin ; Non-classical steroid signaling ;Oxytocin receptor ; Estrogen receptor-alpha ; Estrogen receptor-beta ;Bovine ovary http://www.sciencedirect.com/science/article/pii/S0303720713001615 doi:10.1016/j.mce.2013.04.016 doi:10.1016/j.mce.2013.04.016 |
| spellingShingle | Oxytocin ; Non-classical steroid signaling ;Oxytocin receptor ; Estrogen receptor-alpha ; Estrogen receptor-beta ;Bovine ovary Ivell, Richard Dai, Yanzhenzi Mann, Navdeep Anand-Ivell, Ravinder Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model |
| title | Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model |
| title_full | Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model |
| title_fullStr | Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model |
| title_full_unstemmed | Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model |
| title_short | Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model |
| title_sort | non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model |
| topic | Oxytocin ; Non-classical steroid signaling ;Oxytocin receptor ; Estrogen receptor-alpha ; Estrogen receptor-beta ;Bovine ovary |
| url | https://eprints.nottingham.ac.uk/41439/ https://eprints.nottingham.ac.uk/41439/ https://eprints.nottingham.ac.uk/41439/ |