Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring
Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. It is not known, however, whether such early gestational and/or lactational exposure can influence the...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Nature Publishing Group
2013
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/41425/ |
| _version_ | 1848796270038089728 |
|---|---|
| author | Ivell, Richard Heng, Kee Nicholson, Helen Anand-Ivell, Ravinder |
| author_facet | Ivell, Richard Heng, Kee Nicholson, Helen Anand-Ivell, Ravinder |
| author_sort | Ivell, Richard |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. It is not known, however, whether such early gestational and/or lactational exposure can influence the later adult-type Leydig cell phenotype. In this study, Sprague-Dawley rats were exposed to dibutyl phthalate (DBP; from gestational day (GD) 14.5 to postnatal day (PND) 6) or diethylstilbestrol (DES; from GD14.5 to GD16.5) during a short gestational/lactational window, and male offspring subsequently analysed for various postnatal testicular parameters. All offspring remained in good health throughout the study. Maternal xenobiotic treatment appeared to modify specific Leydig cell gene expression in male offspring, particularly during the dynamic phase of mid-puberty, with serum INSL3 concentrations showing that these compounds led to a faster attainment of peak values, and a modest acceleration of the pubertal trajectory. Part of this effect appeared to be due to a treatment-specific impact on Leydig cell proliferation during puberty for both xenobiotics. Taken together, these results support the notion that maternal exposure to certain xenobiotics can also influence the development of the adult-type Leydig cell population, possibly through an effect on the Leydig stem cell population. |
| first_indexed | 2025-11-14T19:45:18Z |
| format | Article |
| id | nottingham-41425 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:45:18Z |
| publishDate | 2013 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-414252020-05-04T16:35:39Z https://eprints.nottingham.ac.uk/41425/ Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring Ivell, Richard Heng, Kee Nicholson, Helen Anand-Ivell, Ravinder Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. It is not known, however, whether such early gestational and/or lactational exposure can influence the later adult-type Leydig cell phenotype. In this study, Sprague-Dawley rats were exposed to dibutyl phthalate (DBP; from gestational day (GD) 14.5 to postnatal day (PND) 6) or diethylstilbestrol (DES; from GD14.5 to GD16.5) during a short gestational/lactational window, and male offspring subsequently analysed for various postnatal testicular parameters. All offspring remained in good health throughout the study. Maternal xenobiotic treatment appeared to modify specific Leydig cell gene expression in male offspring, particularly during the dynamic phase of mid-puberty, with serum INSL3 concentrations showing that these compounds led to a faster attainment of peak values, and a modest acceleration of the pubertal trajectory. Part of this effect appeared to be due to a treatment-specific impact on Leydig cell proliferation during puberty for both xenobiotics. Taken together, these results support the notion that maternal exposure to certain xenobiotics can also influence the development of the adult-type Leydig cell population, possibly through an effect on the Leydig stem cell population. Nature Publishing Group 2013-03-01 Article PeerReviewed Ivell, Richard, Heng, Kee, Nicholson, Helen and Anand-Ivell, Ravinder (2013) Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring. Asian Journal of Andrology, 15 (2). pp. 261-268. ISSN 1008-682X Diethylstilbestrol (DES); INSL3; Leydig cells; dibutyl phthalate (DBP); puberty; testis http://www.asiaandro.com/Abstract.asp?doi=10.1038/aja.2012.138 doi:10.1038/aja.2012.138 doi:10.1038/aja.2012.138 |
| spellingShingle | Diethylstilbestrol (DES); INSL3; Leydig cells; dibutyl phthalate (DBP); puberty; testis Ivell, Richard Heng, Kee Nicholson, Helen Anand-Ivell, Ravinder Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring |
| title | Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring |
| title_full | Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring |
| title_fullStr | Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring |
| title_full_unstemmed | Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring |
| title_short | Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring |
| title_sort | brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type leydig cell development in male offspring |
| topic | Diethylstilbestrol (DES); INSL3; Leydig cells; dibutyl phthalate (DBP); puberty; testis |
| url | https://eprints.nottingham.ac.uk/41425/ https://eprints.nottingham.ac.uk/41425/ https://eprints.nottingham.ac.uk/41425/ |