Bioprinting using mechanically robust core-shell cell-laden hydrogel strands
The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combination of optimal biological and mechanical properties in bioprinted constructs. Here, a novel bioprintin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Wiley
2017
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| Online Access: | https://eprints.nottingham.ac.uk/41404/ |
| _version_ | 1848796266453008384 |
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| author | Mistry, Pritesh Aied, Ahmed Alexander, Morgan R. Shakesheff, Kevin Bennett, Andrew Yang, Jing |
| author_facet | Mistry, Pritesh Aied, Ahmed Alexander, Morgan R. Shakesheff, Kevin Bennett, Andrew Yang, Jing |
| author_sort | Mistry, Pritesh |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combination of optimal biological and mechanical properties in bioprinted constructs. Here, a novel bioprinting method that utilises core-shell cell-laden strands with a mechanically robust shell and an extracellular matrix (ECM)-like core has been developed. Cells encapsulated in the strands demonstrate high cell viability and tissue-like functions during cultivation. This process of bioprinting using core-shell strands with optimal biochemical and biomechanical properties represents a new strategy for fabricating functional human tissues and organs. |
| first_indexed | 2025-11-14T19:45:15Z |
| format | Article |
| id | nottingham-41404 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:45:15Z |
| publishDate | 2017 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-414042020-05-04T18:36:04Z https://eprints.nottingham.ac.uk/41404/ Bioprinting using mechanically robust core-shell cell-laden hydrogel strands Mistry, Pritesh Aied, Ahmed Alexander, Morgan R. Shakesheff, Kevin Bennett, Andrew Yang, Jing The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combination of optimal biological and mechanical properties in bioprinted constructs. Here, a novel bioprinting method that utilises core-shell cell-laden strands with a mechanically robust shell and an extracellular matrix (ECM)-like core has been developed. Cells encapsulated in the strands demonstrate high cell viability and tissue-like functions during cultivation. This process of bioprinting using core-shell strands with optimal biochemical and biomechanical properties represents a new strategy for fabricating functional human tissues and organs. Wiley 2017-02-03 Article PeerReviewed Mistry, Pritesh, Aied, Ahmed, Alexander, Morgan R., Shakesheff, Kevin, Bennett, Andrew and Yang, Jing (2017) Bioprinting using mechanically robust core-shell cell-laden hydrogel strands. Macromolecular Bioscience . ISSN 1616-5195 http://onlinelibrary.wiley.com/doi/10.1002/mabi.201600472/abstract?system doi:10.1002/mabi.201600472 doi:10.1002/mabi.201600472 |
| spellingShingle | Mistry, Pritesh Aied, Ahmed Alexander, Morgan R. Shakesheff, Kevin Bennett, Andrew Yang, Jing Bioprinting using mechanically robust core-shell cell-laden hydrogel strands |
| title | Bioprinting using mechanically robust core-shell cell-laden hydrogel strands |
| title_full | Bioprinting using mechanically robust core-shell cell-laden hydrogel strands |
| title_fullStr | Bioprinting using mechanically robust core-shell cell-laden hydrogel strands |
| title_full_unstemmed | Bioprinting using mechanically robust core-shell cell-laden hydrogel strands |
| title_short | Bioprinting using mechanically robust core-shell cell-laden hydrogel strands |
| title_sort | bioprinting using mechanically robust core-shell cell-laden hydrogel strands |
| url | https://eprints.nottingham.ac.uk/41404/ https://eprints.nottingham.ac.uk/41404/ https://eprints.nottingham.ac.uk/41404/ |