Toward blueprints for network architecture, biophysical dynamics, and signal transduction
We review mathematical aspects of biophysical dynamics, signal transduction and network architecture that have been used to uncover functionally significant relations between the dynamics of single neurons and the networks they compose. We focus on examples that combine insights from these three ar...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
2006
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| Online Access: | https://eprints.nottingham.ac.uk/414/ |
| _version_ | 1848790409675800576 |
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| author | Coombes, Stephen Doiron, Brent Josic, Kresimir Shea-Brown, Eric |
| author_facet | Coombes, Stephen Doiron, Brent Josic, Kresimir Shea-Brown, Eric |
| author_sort | Coombes, Stephen |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We review mathematical aspects of biophysical dynamics, signal transduction and network architecture that have been used to uncover functionally significant relations between the dynamics of single neurons and the networks they compose. We focus on examples that combine insights from these three areas to expand our understanding of systems neuroscience. These range from single neuron coding to models of decision making and electrosensory discrimination by networks and populations, as well as coincidence detection in pairs of dendrites and the dynamics of large networks of excitable dendritic spines. We conclude by describing some of the challenges that lie ahead as the applied mathematics community seeks to provide the tools that will ultimately underpin systems neuroscience. |
| first_indexed | 2025-11-14T18:12:10Z |
| format | Article |
| id | nottingham-414 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:12:10Z |
| publishDate | 2006 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-4142020-05-04T20:29:22Z https://eprints.nottingham.ac.uk/414/ Toward blueprints for network architecture, biophysical dynamics, and signal transduction Coombes, Stephen Doiron, Brent Josic, Kresimir Shea-Brown, Eric We review mathematical aspects of biophysical dynamics, signal transduction and network architecture that have been used to uncover functionally significant relations between the dynamics of single neurons and the networks they compose. We focus on examples that combine insights from these three areas to expand our understanding of systems neuroscience. These range from single neuron coding to models of decision making and electrosensory discrimination by networks and populations, as well as coincidence detection in pairs of dendrites and the dynamics of large networks of excitable dendritic spines. We conclude by describing some of the challenges that lie ahead as the applied mathematics community seeks to provide the tools that will ultimately underpin systems neuroscience. 2006-09 Article PeerReviewed Coombes, Stephen, Doiron, Brent, Josic, Kresimir and Shea-Brown, Eric (2006) Toward blueprints for network architecture, biophysical dynamics, and signal transduction. |
| spellingShingle | Coombes, Stephen Doiron, Brent Josic, Kresimir Shea-Brown, Eric Toward blueprints for network architecture, biophysical dynamics, and signal transduction |
| title | Toward blueprints for network architecture, biophysical dynamics, and signal transduction |
| title_full | Toward blueprints for network architecture, biophysical dynamics, and signal transduction |
| title_fullStr | Toward blueprints for network architecture, biophysical dynamics, and signal transduction |
| title_full_unstemmed | Toward blueprints for network architecture, biophysical dynamics, and signal transduction |
| title_short | Toward blueprints for network architecture, biophysical dynamics, and signal transduction |
| title_sort | toward blueprints for network architecture, biophysical dynamics, and signal transduction |
| url | https://eprints.nottingham.ac.uk/414/ |