Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families
Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of oth...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Oxford University Press
2016
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/41313/ |
| _version_ | 1848796246555230208 |
|---|---|
| author | Chou, I-Jun Kuo, Chang-Fu Huang, Yu-Shu Grainge, Matthew J. Valdes, Ana M. See, Lai-Chu Yu, Kuang-Hui Luo, Shue-Fen Huang, Lu-Shuang Tseng, Wen-Yi Zhang, Weiya Doherty, Michael |
| author_facet | Chou, I-Jun Kuo, Chang-Fu Huang, Yu-Shu Grainge, Matthew J. Valdes, Ana M. See, Lai-Chu Yu, Kuang-Hui Luo, Shue-Fen Huang, Lu-Shuang Tseng, Wen-Yi Zhang, Weiya Doherty, Michael |
| author_sort | Chou, I-Jun |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric diseases, in relatives of people with schizophrenia using the Taiwan National Health Insurance Database. The study population included individuals with affected first-degree or second-degree relatives identified from all beneficiaries (n = 23 422 955) registered in 2013. Diagnoses of schizophrenia made by psychiatrists were ascertained between January 1, 1996 and December 31, 2013. Having an affected co-twin, first-degree relative, second-degree relative, or spouse was associated with an adjusted RR (95% CI) of 37.86 (30.55-46.92), 6.30 (6.09-6.53), 2.44 (1.91-3.12), and 1.88 (1.64-2.15), respectively. Compared with the general population, individuals with one affected first-degree relative had a RR (95% CI) of 6.00 (5.79-6.22) and those with 2 or more had a RR (95% CI) of 14.66 (13.00-16.53) for schizophrenia. The accountability for the phenotypic variance of schizophrenia was 47.3% for genetic factors, 15.5% for shared environmental factors, and 37.2% for non-shared environmental factors. The RR (95% CI) in individuals with a first-degree relative with schizophrenia was 3.49 (3.34-3.64) for mood disorders and 3.91 (3.35-4.57) for delusional disorders. A family history of schizophrenia is therefore associated with a higher risk of developing schizophrenia, mood disorders, and delusional disorders. Heritability and environmental factors each account for half of the phenotypic variance of schizophrenia. |
| first_indexed | 2025-11-14T19:44:56Z |
| format | Article |
| id | nottingham-41313 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:44:56Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-413132020-05-04T18:20:24Z https://eprints.nottingham.ac.uk/41313/ Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families Chou, I-Jun Kuo, Chang-Fu Huang, Yu-Shu Grainge, Matthew J. Valdes, Ana M. See, Lai-Chu Yu, Kuang-Hui Luo, Shue-Fen Huang, Lu-Shuang Tseng, Wen-Yi Zhang, Weiya Doherty, Michael Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric diseases, in relatives of people with schizophrenia using the Taiwan National Health Insurance Database. The study population included individuals with affected first-degree or second-degree relatives identified from all beneficiaries (n = 23 422 955) registered in 2013. Diagnoses of schizophrenia made by psychiatrists were ascertained between January 1, 1996 and December 31, 2013. Having an affected co-twin, first-degree relative, second-degree relative, or spouse was associated with an adjusted RR (95% CI) of 37.86 (30.55-46.92), 6.30 (6.09-6.53), 2.44 (1.91-3.12), and 1.88 (1.64-2.15), respectively. Compared with the general population, individuals with one affected first-degree relative had a RR (95% CI) of 6.00 (5.79-6.22) and those with 2 or more had a RR (95% CI) of 14.66 (13.00-16.53) for schizophrenia. The accountability for the phenotypic variance of schizophrenia was 47.3% for genetic factors, 15.5% for shared environmental factors, and 37.2% for non-shared environmental factors. The RR (95% CI) in individuals with a first-degree relative with schizophrenia was 3.49 (3.34-3.64) for mood disorders and 3.91 (3.35-4.57) for delusional disorders. A family history of schizophrenia is therefore associated with a higher risk of developing schizophrenia, mood disorders, and delusional disorders. Heritability and environmental factors each account for half of the phenotypic variance of schizophrenia. Oxford University Press 2016-11-21 Article PeerReviewed Chou, I-Jun, Kuo, Chang-Fu, Huang, Yu-Shu, Grainge, Matthew J., Valdes, Ana M., See, Lai-Chu, Yu, Kuang-Hui, Luo, Shue-Fen, Huang, Lu-Shuang, Tseng, Wen-Yi, Zhang, Weiya and Doherty, Michael (2016) Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families. Schizophrenia Bulletin . ISSN 1745-1701 delusional disorders familial aggregation heritability mood disorders schizophrenia https://academic.oup.com/schizophreniabulletin/article-lookup/doi/10.1093/schbul/sbw159 doi:10.1093/schbul/sbw159 doi:10.1093/schbul/sbw159 |
| spellingShingle | delusional disorders familial aggregation heritability mood disorders schizophrenia Chou, I-Jun Kuo, Chang-Fu Huang, Yu-Shu Grainge, Matthew J. Valdes, Ana M. See, Lai-Chu Yu, Kuang-Hui Luo, Shue-Fen Huang, Lu-Shuang Tseng, Wen-Yi Zhang, Weiya Doherty, Michael Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families |
| title | Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families |
| title_full | Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families |
| title_fullStr | Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families |
| title_full_unstemmed | Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families |
| title_short | Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families |
| title_sort | familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families |
| topic | delusional disorders familial aggregation heritability mood disorders schizophrenia |
| url | https://eprints.nottingham.ac.uk/41313/ https://eprints.nottingham.ac.uk/41313/ https://eprints.nottingham.ac.uk/41313/ |