The genome landscape of indigenous African cattle
Background: The history of African indigenous cattle and their adaptation to environmental and human selection pressure is at the root of their remarkable diversity. Characterization of this diversity is an essential step towards understanding the genomic basis of productivity and adaptation to surv...
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| Format: | Article |
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BioMed Central
2017
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| Online Access: | https://eprints.nottingham.ac.uk/41024/ |
| _version_ | 1848796180617625600 |
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| author | Kim, Jaemin Hanotte, Olivier Okeyo, Ally Mwai Dessie, Tadelle Bashir, Salim Diallo, Boubacar Agaba, Morris Kim, Kwondo Kwak, Woori Sung, Samsun Seo, Minseok Jeong, Hyeonsoo Taehyung, Kwon Taye, Mengistie Song, Ki-Duk Lim, Dajeong Cho, Seoae Lee, Hyun-Jeong Yoon, Duhak Oh, Sung Jong Kemp, Stephen Lee, Hak-Kyo Kim, Heebal |
| author_facet | Kim, Jaemin Hanotte, Olivier Okeyo, Ally Mwai Dessie, Tadelle Bashir, Salim Diallo, Boubacar Agaba, Morris Kim, Kwondo Kwak, Woori Sung, Samsun Seo, Minseok Jeong, Hyeonsoo Taehyung, Kwon Taye, Mengistie Song, Ki-Duk Lim, Dajeong Cho, Seoae Lee, Hyun-Jeong Yoon, Duhak Oh, Sung Jong Kemp, Stephen Lee, Hak-Kyo Kim, Heebal |
| author_sort | Kim, Jaemin |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: The history of African indigenous cattle and their adaptation to environmental and human selection pressure is at the root of their remarkable diversity. Characterization of this diversity is an essential step towards understanding the genomic basis of productivity and adaptation to survival under African farming systems.
Results: We analyze patterns of African cattle genetic variation by sequencing 48 genomes from five indigenous populations and comparing them to the genomes of 53 commercial taurine breeds. We find the highest genetic diversity among African zebu and sanga cattle. Our search for genomic regions under selection reveals signatures of selection for environmental adaptive traits. In particular, we identify signatures of selection including genes and/ or pathways controlling anemia and feeding behavior in the trypanotolerant N’Dama, coat color and horn development in Ankole, and heat tolerance and tick resistance across African cattle especially in zebu breeds.
Conclusions: Our findings unravel at the genome-wide level, the unique adaptive diversity of African cattle while emphasizing the opportunities for sustainable improvement of livestock productivity on the continent. |
| first_indexed | 2025-11-14T19:43:53Z |
| format | Article |
| id | nottingham-41024 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:43:53Z |
| publishDate | 2017 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-410242020-05-04T18:34:12Z https://eprints.nottingham.ac.uk/41024/ The genome landscape of indigenous African cattle Kim, Jaemin Hanotte, Olivier Okeyo, Ally Mwai Dessie, Tadelle Bashir, Salim Diallo, Boubacar Agaba, Morris Kim, Kwondo Kwak, Woori Sung, Samsun Seo, Minseok Jeong, Hyeonsoo Taehyung, Kwon Taye, Mengistie Song, Ki-Duk Lim, Dajeong Cho, Seoae Lee, Hyun-Jeong Yoon, Duhak Oh, Sung Jong Kemp, Stephen Lee, Hak-Kyo Kim, Heebal Background: The history of African indigenous cattle and their adaptation to environmental and human selection pressure is at the root of their remarkable diversity. Characterization of this diversity is an essential step towards understanding the genomic basis of productivity and adaptation to survival under African farming systems. Results: We analyze patterns of African cattle genetic variation by sequencing 48 genomes from five indigenous populations and comparing them to the genomes of 53 commercial taurine breeds. We find the highest genetic diversity among African zebu and sanga cattle. Our search for genomic regions under selection reveals signatures of selection for environmental adaptive traits. In particular, we identify signatures of selection including genes and/ or pathways controlling anemia and feeding behavior in the trypanotolerant N’Dama, coat color and horn development in Ankole, and heat tolerance and tick resistance across African cattle especially in zebu breeds. Conclusions: Our findings unravel at the genome-wide level, the unique adaptive diversity of African cattle while emphasizing the opportunities for sustainable improvement of livestock productivity on the continent. BioMed Central 2017-02-20 Article PeerReviewed Kim, Jaemin, Hanotte, Olivier, Okeyo, Ally Mwai, Dessie, Tadelle, Bashir, Salim, Diallo, Boubacar, Agaba, Morris, Kim, Kwondo, Kwak, Woori, Sung, Samsun, Seo, Minseok, Jeong, Hyeonsoo, Taehyung, Kwon, Taye, Mengistie, Song, Ki-Duk, Lim, Dajeong, Cho, Seoae, Lee, Hyun-Jeong, Yoon, Duhak, Oh, Sung Jong, Kemp, Stephen, Lee, Hak-Kyo and Kim, Heebal (2017) The genome landscape of indigenous African cattle. Genome Biology, 18 . 34/1-34/14. ISSN 1474-760X African cattle Genome Adaptation Diversity http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1153-y doi:10.1186/s13059-017-1153-y doi:10.1186/s13059-017-1153-y |
| spellingShingle | African cattle Genome Adaptation Diversity Kim, Jaemin Hanotte, Olivier Okeyo, Ally Mwai Dessie, Tadelle Bashir, Salim Diallo, Boubacar Agaba, Morris Kim, Kwondo Kwak, Woori Sung, Samsun Seo, Minseok Jeong, Hyeonsoo Taehyung, Kwon Taye, Mengistie Song, Ki-Duk Lim, Dajeong Cho, Seoae Lee, Hyun-Jeong Yoon, Duhak Oh, Sung Jong Kemp, Stephen Lee, Hak-Kyo Kim, Heebal The genome landscape of indigenous African cattle |
| title | The genome landscape of indigenous African cattle |
| title_full | The genome landscape of indigenous African cattle |
| title_fullStr | The genome landscape of indigenous African cattle |
| title_full_unstemmed | The genome landscape of indigenous African cattle |
| title_short | The genome landscape of indigenous African cattle |
| title_sort | genome landscape of indigenous african cattle |
| topic | African cattle Genome Adaptation Diversity |
| url | https://eprints.nottingham.ac.uk/41024/ https://eprints.nottingham.ac.uk/41024/ https://eprints.nottingham.ac.uk/41024/ |