Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction

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Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction

Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer. Virtual screening identified certain 3,4,5-trisubstituted 4H-1,2,4-triazoles as moderately potent inhibitors of this in...

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Bibliographic Details
Main Authors:	Reddy, Tummala R.K., Li, Chan, Guo, Xiaoxia, Fischer, Peter M., Dekker, Lodewijk V.
Format:	Article
Published:	Elsevier 2014
Subjects:	S100 proteins; Annexins; Docking; Triazole
Online Access:	https://eprints.nottingham.ac.uk/40928/

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