Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry
In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs with or without medial coronoid process disease (M...
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BMJ Publishing Group
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40899/ |
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| author | Davies, M. West, J. Williams, C. Gardner, David S. |
| author_facet | Davies, M. West, J. Williams, C. Gardner, David S. |
| author_sort | Davies, M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs with or without medial coronoid process disease (MCPD). Dogs with MCPD have a different profile of minerals known to influence metalloenzymes involved in endochondral ossification. After cleansing, chelation and acid digestion of hair samples (n=79 in total: control dogs, n=70 v MCPD, n=9), mineral profile (7 major and 25 trace elements) was determined by inductively coupled plasma-mass spectrometry. Dogs were of similar age (control, 4.05 [1.85-7.70] v MCPD, 4.30 [3.25-6.53] median (IQR) years; P=0.78) and gender (control, n=43/27 v MCPD, n=4/5 males/females). 28/70 (40 per cent) of control and 8/9 (88 per cent) of MCPD dogs were neutered, respectively. Hair from dogs with MCPD contained significantly lower amounts (µg/g/DM) of copper, sulphur and zinc (all at P<0.001). Age, sex and neutered status had no effect on hair mineral status. Based on hair analysis, a role for mineral imbalance including copper, sulphur and zinc in the aetiopathogenesis of canine MCPD is suggested. Hair mineral analysis may prove useful as a biomarker for susceptible puppies. |
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| format | Article |
| id | nottingham-40899 |
| institution | University of Nottingham Malaysia Campus |
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| publishDate | 2017 |
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| spelling | nottingham-408992024-08-15T15:21:56Z https://eprints.nottingham.ac.uk/40899/ Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry Davies, M. West, J. Williams, C. Gardner, David S. In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs with or without medial coronoid process disease (MCPD). Dogs with MCPD have a different profile of minerals known to influence metalloenzymes involved in endochondral ossification. After cleansing, chelation and acid digestion of hair samples (n=79 in total: control dogs, n=70 v MCPD, n=9), mineral profile (7 major and 25 trace elements) was determined by inductively coupled plasma-mass spectrometry. Dogs were of similar age (control, 4.05 [1.85-7.70] v MCPD, 4.30 [3.25-6.53] median (IQR) years; P=0.78) and gender (control, n=43/27 v MCPD, n=4/5 males/females). 28/70 (40 per cent) of control and 8/9 (88 per cent) of MCPD dogs were neutered, respectively. Hair from dogs with MCPD contained significantly lower amounts (µg/g/DM) of copper, sulphur and zinc (all at P<0.001). Age, sex and neutered status had no effect on hair mineral status. Based on hair analysis, a role for mineral imbalance including copper, sulphur and zinc in the aetiopathogenesis of canine MCPD is suggested. Hair mineral analysis may prove useful as a biomarker for susceptible puppies. BMJ Publishing Group 2017-02-20 Article PeerReviewed Davies, M., West, J., Williams, C. and Gardner, David S. (2017) Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry. Veterinary Record, 180 (18). p. 448. ISSN 0042-4900 copper; medial coronoid process disease; minerals; zinc http://veterinaryrecord.bmj.com/content/180/18/448 doi:10.1136/vr.103953 doi:10.1136/vr.103953 |
| spellingShingle | copper; medial coronoid process disease; minerals; zinc Davies, M. West, J. Williams, C. Gardner, David S. Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry |
| title | Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry |
| title_full | Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry |
| title_fullStr | Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry |
| title_full_unstemmed | Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry |
| title_short | Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry |
| title_sort | mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry |
| topic | copper; medial coronoid process disease; minerals; zinc |
| url | https://eprints.nottingham.ac.uk/40899/ https://eprints.nottingham.ac.uk/40899/ https://eprints.nottingham.ac.uk/40899/ |