The antimalarial drug quinine interferes with serotonin biosynthesis and action

QR Code

The antimalarial drug quinine interferes with serotonin biosynthesis and action

The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan, and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As tryptophan is a precursor of the neurotransmitter...

Full description

Bibliographic Details
Main Authors:	Islahudin, Farida, Tindall, Sarah M., Mellor, Ian R., Swift, Karen, Christensen, Hans E.M., Fone, Kevin C.F., Pleass, Richard J., Avery, Simon V.
Format:	Article
Published:	Nature Publishing Group 2014
Subjects:	drug development enzyme mechanisms malaria mechanism of action
Online Access:	https://eprints.nottingham.ac.uk/40885/

Similar Items

The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials
by: Vallieres, Cindy, et al.
Published: (2017)

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth
by: Lalève, Anaïs, et al.
Published: (2016)

Modelling the time course of antimalarial parasite killing: A tour of animal and human models, translation and challenges
by: Patel, K., et al.
Published: (2015)

Pharmacodynamic studies of antimalarial drugs in a murine malaria model
by: Moore, Brioni R.
Published: (2011)

Comparison between survival and severe models of malaria infection for better understanding of the underlying disease pathogenesis
by: Chong, Wing Chui
Published: (2013)

Cell wall perturbation sensitizes fungi to the antimalarial drug chloroquine
by: Islahudin, Farida, et al.
Published: (2013)

The synthesis of the antimalarial compound hydroxypiperaquine (HPQ)
by: Mohammed, Yousuf Hussain
Published: (2007)

Heterologous expression of a novel drug transporter from the malaria parasite alters resistance to quinoline antimalarials
by: Tindall, Sarah M., et al.
Published: (2018)

Climatological and socioeconomic factors that predispose to the risk of malaria in Sudan
by: Mohammed, Ibrahim Musa Hassan
Published: (2012)

Determining malaria risk factors in Abuja, Nigeria using various statistical approaches
by: Segun, Oguntade Emmanuel
Published: (2018)

Effects of interleukin-18 modulation on the pathogenesis of malaria infection
by: Jabbarzare, Marzieh
Published: (2013)

Modulation of receptor for advanced glycation end products signal transduction pathway as therapeutic option for malaria therapy
by: Chuah, Yaw Kuang
Published: (2015)

Ex vivo antiplasmodial activity of Quassia Borneensis Noot. (SIMAROUBACEAE) extracts against mice erythrocytes infected by Plasmodium Berghei NK 65 / Ahmad Rohi Ghazali, Julenah Ag Nuddin, Siti Nurfarhana Sabireen, Wan Marahaini Wan Razali and Shafariatul Akmar Ishak
by: Ghazali, Ahmad Rohi, et al.
Published: (2013)

Role, involvement and potential of interleukin-27 as an immunotherapeutic target in murine malaria
by: Fazalul Rahiman, Siti Sarah
Published: (2012)

Predictors of malaria among pregnant women attending ante-natal clinic in general hospital in Zamfara State, Nigeria
by: Hadiza, Kallamu
Published: (2015)

Screening the medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18
by: Paiardini, Alessandro, et al.
Published: (2015)

Development of microweir structure by lithographic fabrication process for malaria cell separation
by: Sivaraj, Lalitha
Published: (2016)

Anti-Malarial Activity of Goniothalamus Scortechinii King
by: Md Yusuf, Noor Azian
Published: (2006)

Factors associated with health seeking behavior for malaria treatment among caregivers of under-five children with fever in Imo State, Nigeria
by: Sampson, Emilia Oluchi
Published: (2018)

Enzymatic Extraction and Modification, and Frying Stability of Moringa Oleifera Seed Oil.
by: Mohammed, Abdulkarim Sabo
Published: (2006)

A metabolomic analytical approach permits identification of urinary biomarkers for Plasmodium falciparum infection: a case–control study
by: Abdelrazig, Salah M.A., et al.
Published: (2017)

Prevalence and associated risk factors of malaria among adults in East Shewa Zone of Oromia Regional State, Ethiopia: a cross-sectional study
by: Tadesse, Frew, et al.
Published: (2017)

Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek
by: Raja Yahya, Mohd Fakharul Zaman, et al.
Published: (2012)

Knowledge and attitude of insecticide-treated net use in malaria prevention and its associated factors among pregnant women in Umuahia North, Nigeria
by: Onyinyechi, Opara Monica
Published: (2017)

An immunosuppressive therapeutic approach targeting interleukin-35 for controlling excessive immunoinflammatory response during Plasmodium berghei ANKA infection in mice
by: Omenesa, Ramatu Bello
Published: (2019)

Leaf pigmentation in Cannabis sativa: Characterization of anthocyanin biosynthesis in colorful Cannabis varieties
by: Gagalova, Kristina K., et al.
Published: (2024)

Kinetics, crystallization, and structural elucidation of thermostable D311E T1 lipase variant from Geobacillus zalihae
by: Ruslan, Rudzanna
Published: (2013)

Computational study of T1 lipase activation and metallolipase engineering using modified T1 lipase as scaffold
by: Abdul Rahman, Mohd Zulhilmi
Published: (2013)

Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad
by: Ahmad, Faujan
Published: (2010)

The effect of glycerol to enzyme ratio in enzymatic glycerolysis
by: Yeoh, Chiou Moi, et al.
Published: (2008)

Optimisation of enzyme-aided peeling of musk lime (Citrus mitis B.) and development of its candied peel
by: Adnan, Hazniza
Published: (2003)

Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection
by: Chukwuanukwu, Rebecca C., et al.
Published: (2016)

Malaria prevalance and socio-acceptability of insecticide-treated bed nets for malaria prevention in Mazabuka, Zambia
by: Banda, Jane
Published: (2013)

Statistical approach for enzyme production using response surface methodology and structure prediction of thermostable organic solvent-tolerant rand protease
by: Husein, Randa Abdel Kareem
Published: (2017)

Contribution of serotonin and dopamine to changes in core body temperature and locomotor activity in rats following repeated administration of mephedrone
by: Shortall, Sinead E., et al.
Published: (2015)

Nutritional composition and angiotensin-converting enzyme inhibitory activity of blue lupin (Lupinus angustifolius L.)
by: Chin, Ying Yee
Published: (2017)

Expression of recombinant thermostable W200R protease in Pichia pastoris
by: Mohamad Sultan, Muhamad Zarir
Published: (2011)

Fungal Screening and Isolation of Cellulolytic, Mannan and Protein Degrading Enzyme Producers in Palm Kernel Cake Solid State Fermentation
by: Farida Asras, Mohd Fazli
Published: (2009)

Serotonin controlling feeding and satiety
by: Voigt, Jörg-Peter, et al.
Published: (2015)

Enzyme Catalyzed Synthesis of Fatty Monoethanolamides from Palm Kernel Oil Fractions
by: Yap, Chiew Lin
Published: (1998)