Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease

Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease

Serine/arginine-protein kinase 1 (SRPK1) regulates alternative splicing of VEGF-A to pro-angiogenic isoforms and SRPK1 inhibition can restore the balance of pro/antiangiogenic isoforms to normal physiological levels. The lack of potency and selectivity of available compounds has limited development...

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Bibliographic Details
Main Authors: Batson, Jennifer, Toop, Hamish D., Redondo, Clara, Babaei-Jadidi, Roya, Chaikaud, Apirat, Wearmouth, Stephen F., Gibbons, Brian, Allen, Claire, Tallant, Cynthia, Zhang, Jingxue, Du, Chunyun, Hancox, Jules C., Hawtrey, Tom, Da Rocha, Joana, Griffith, Renate, Knapp, Stefan, Bates, David O., Morris, Jonathan C.
Format: Article
Published: American Chemical Society 2017
Online Access:https://eprints.nottingham.ac.uk/40843/

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