A distinct bacterial dysbiosis associated skin inflammation in ovine footrot
Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study s...
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| Format: | Article |
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Nature Publishing Group
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40730/ |
| _version_ | 1848796127094112256 |
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| author | Maboni, G. Blanchard, Adam M. Frosth, S. Stewart, Ceri E. Emes, Richard D. Tötemeyer, Sabine |
| author_facet | Maboni, G. Blanchard, Adam M. Frosth, S. Stewart, Ceri E. Emes, Richard D. Tötemeyer, Sabine |
| author_sort | Maboni, G. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high D. nodosus load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation. Treponema (34%), Mycoplasma(29%) and Porphyromonas (15%) were the most abundant genera associated with high levels of inflammation in footrot. In contrast, Acinetobacter (25%), Corynebacteria (17%) and Flavobacterium (17%) were the most abundant genera associated with high levels of inflammation in healthy feet. This demonstrates for the first time there is a distinct microbial community associated with footrot and high cytokine expression. |
| first_indexed | 2025-11-14T19:43:02Z |
| format | Article |
| id | nottingham-40730 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:43:02Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-407302020-05-04T18:39:03Z https://eprints.nottingham.ac.uk/40730/ A distinct bacterial dysbiosis associated skin inflammation in ovine footrot Maboni, G. Blanchard, Adam M. Frosth, S. Stewart, Ceri E. Emes, Richard D. Tötemeyer, Sabine Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high D. nodosus load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation. Treponema (34%), Mycoplasma(29%) and Porphyromonas (15%) were the most abundant genera associated with high levels of inflammation in footrot. In contrast, Acinetobacter (25%), Corynebacteria (17%) and Flavobacterium (17%) were the most abundant genera associated with high levels of inflammation in healthy feet. This demonstrates for the first time there is a distinct microbial community associated with footrot and high cytokine expression. Nature Publishing Group 2017-03-24 Article PeerReviewed Maboni, G., Blanchard, Adam M., Frosth, S., Stewart, Ceri E., Emes, Richard D. and Tötemeyer, Sabine (2017) A distinct bacterial dysbiosis associated skin inflammation in ovine footrot. Scientific Reports, 7 . 45220/1-45220/11. ISSN 2045-2322 http://www.nature.com/articles/srep45220 doi:10.1038/srep45220 doi:10.1038/srep45220 |
| spellingShingle | Maboni, G. Blanchard, Adam M. Frosth, S. Stewart, Ceri E. Emes, Richard D. Tötemeyer, Sabine A distinct bacterial dysbiosis associated skin inflammation in ovine footrot |
| title | A distinct bacterial dysbiosis associated skin inflammation in ovine footrot |
| title_full | A distinct bacterial dysbiosis associated skin inflammation in ovine footrot |
| title_fullStr | A distinct bacterial dysbiosis associated skin inflammation in ovine footrot |
| title_full_unstemmed | A distinct bacterial dysbiosis associated skin inflammation in ovine footrot |
| title_short | A distinct bacterial dysbiosis associated skin inflammation in ovine footrot |
| title_sort | distinct bacterial dysbiosis associated skin inflammation in ovine footrot |
| url | https://eprints.nottingham.ac.uk/40730/ https://eprints.nottingham.ac.uk/40730/ https://eprints.nottingham.ac.uk/40730/ |