Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

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Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

Due to the highly restricted species-tropism of Hepatitis C virus (HCV) a limited number of animal models exist for pre-clinical evaluation of vaccines and antiviral compounds. The human-liver chimeric mouse model allows heterologous challenge with clinically relevant strains derived from patients....

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Bibliographic Details
Main Authors:	Khera, Tanvi, Todt, Daniel, Vercauteren, Koen, McClure, C. Patrick, Verhoye, Lieven, Farhoudi, Ali, Bhuju, Sabin, Geffers, Robert, Baumert, Thomas, Steinmann, Eike, Meuleman, Philip, Pietschmann, Thomas, Brown, Richard J.P.
Format:	Article
Published:	Elsevier 2017
Subjects:	HCV protease; Transmission; Founder populations; Longitudinal evolution; RAS emergence
Online Access:	https://eprints.nottingham.ac.uk/40718/

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