International comparative epidemiology of idiopathic pulmonary fibrosis
Background Evidence from the UK suggests the incidence of idiopathic pulmonary fibrosis is increasing, but there is a lack of data from elsewhere in the World. The cause of the disease remains unknown. New anti-fibrotic therapies may increase the use of surgical lung biopsy for accurate diagnosis...
| Main Author: | |
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/40715/ |
| _version_ | 1848796123198652416 |
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| author | Hutchinson, John |
| author_facet | Hutchinson, John |
| author_sort | Hutchinson, John |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background
Evidence from the UK suggests the incidence of idiopathic pulmonary fibrosis is increasing, but there is a lack of data from elsewhere in the World. The cause of the disease remains unknown. New anti-fibrotic therapies may increase the use of surgical lung biopsy for accurate diagnosis, although the risks of this (and other surgery) are not clear.
Methods
Collated international mortality statistics and a systematic review of the literature were used to assess the incidence and mortality of idiopathic pulmonary fibrosis worldwide. Primary care data from the United Kingdom were used to assess the association between recent major surgery and a new diagnosis of idiopathic pulmonary fibrosis. Secondary care data from the United States and United Kingdom were used to assess the risk of surgical lung biopsy for the diagnosis of interstitial lung disease, and the risk of other major surgery in those with idiopathic pulmonary fibrosis.
Results
Mortality from idiopathic pulmonary fibrosis in increasing steadily worldwide. Incidence varies worldwide but is in the range of 3-9 per 100,000 in the West. No association was identified between recent major surgery and a new diagnosis of idiopathic pulmonary fibrosis. Surgical lung biopsy for the diagnosis of interstitial lung disease has an in-hospital mortality of under 2% for elective procedures, but this is higher for non-elective surgery, and in those who are older with co-morbidities. In those with idiopathic pulmonary fibrosis undergoing major surgery, in-hospital mortality was higher than the general population.
Conclusion
Idiopathic pulmonary fibrosis seems to be increasingly common worldwide. Surgery has risks, particularly in unwell older patients, and less invasive diagnostic methods are needed. |
| first_indexed | 2025-11-14T19:42:58Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-40715 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T19:42:58Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-407152025-02-28T13:41:43Z https://eprints.nottingham.ac.uk/40715/ International comparative epidemiology of idiopathic pulmonary fibrosis Hutchinson, John Background Evidence from the UK suggests the incidence of idiopathic pulmonary fibrosis is increasing, but there is a lack of data from elsewhere in the World. The cause of the disease remains unknown. New anti-fibrotic therapies may increase the use of surgical lung biopsy for accurate diagnosis, although the risks of this (and other surgery) are not clear. Methods Collated international mortality statistics and a systematic review of the literature were used to assess the incidence and mortality of idiopathic pulmonary fibrosis worldwide. Primary care data from the United Kingdom were used to assess the association between recent major surgery and a new diagnosis of idiopathic pulmonary fibrosis. Secondary care data from the United States and United Kingdom were used to assess the risk of surgical lung biopsy for the diagnosis of interstitial lung disease, and the risk of other major surgery in those with idiopathic pulmonary fibrosis. Results Mortality from idiopathic pulmonary fibrosis in increasing steadily worldwide. Incidence varies worldwide but is in the range of 3-9 per 100,000 in the West. No association was identified between recent major surgery and a new diagnosis of idiopathic pulmonary fibrosis. Surgical lung biopsy for the diagnosis of interstitial lung disease has an in-hospital mortality of under 2% for elective procedures, but this is higher for non-elective surgery, and in those who are older with co-morbidities. In those with idiopathic pulmonary fibrosis undergoing major surgery, in-hospital mortality was higher than the general population. Conclusion Idiopathic pulmonary fibrosis seems to be increasingly common worldwide. Surgery has risks, particularly in unwell older patients, and less invasive diagnostic methods are needed. 2017-07-14 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/40715/1/John%20Hutchinson%20-%20PhD%20thesis%20-%20final.pdf Hutchinson, John (2017) International comparative epidemiology of idiopathic pulmonary fibrosis. PhD thesis, University of Nottingham. Pulmonary fibrosis; Epidemiology |
| spellingShingle | Pulmonary fibrosis; Epidemiology Hutchinson, John International comparative epidemiology of idiopathic pulmonary fibrosis |
| title | International comparative epidemiology of idiopathic pulmonary fibrosis |
| title_full | International comparative epidemiology of idiopathic pulmonary fibrosis |
| title_fullStr | International comparative epidemiology of idiopathic pulmonary fibrosis |
| title_full_unstemmed | International comparative epidemiology of idiopathic pulmonary fibrosis |
| title_short | International comparative epidemiology of idiopathic pulmonary fibrosis |
| title_sort | international comparative epidemiology of idiopathic pulmonary fibrosis |
| topic | Pulmonary fibrosis; Epidemiology |
| url | https://eprints.nottingham.ac.uk/40715/ |