The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis
Background: The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS. Objective: To perform a systematic review and m...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
Public Library of Science
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40630/ |
| _version_ | 1848796103029293056 |
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| author | Morandi, Elena Tanasescu, Radu Tarlinton, Rachael E. Constantinescu, Cris S. Zhang, Weiya Tench, Christopher R. Gran, Bruno |
| author_facet | Morandi, Elena Tanasescu, Radu Tarlinton, Rachael E. Constantinescu, Cris S. Zhang, Weiya Tench, Christopher R. Gran, Bruno |
| author_sort | Morandi, Elena |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background:
The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.
Objective:
To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients.
Methods:
Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio (OR) and 95% confidence interval (CI) were calculated for association.
Results:
43 reports were extracted (25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HER-15 family). The analysis showed an association between expression of all HERV families and MS. For HERV-W, adequate data was available for meta-analysis. Results from meta-analyses of HERV-W were OR = 22.66 (95%CI 6.32 to 81.20) from 4 studies investigating MSRV/HERV-W(MS-associated retrovirus) envelope mRNA in peripheral blood mononuclear cells, OR = 44.11 (95%CI 12.95 to 150.30) from 6 studies of MSRV/ HERV-W polymerase mRNA in serum/plasma and OR = 6.00 (95%CI 3.35 to 10.74) from 4 studies of MSRV/HERV-W polymerase mRNA in CSF. |
| first_indexed | 2025-11-14T19:42:39Z |
| format | Article |
| id | nottingham-40630 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:42:39Z |
| publishDate | 2017 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-406302020-05-04T18:34:30Z https://eprints.nottingham.ac.uk/40630/ The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis Morandi, Elena Tanasescu, Radu Tarlinton, Rachael E. Constantinescu, Cris S. Zhang, Weiya Tench, Christopher R. Gran, Bruno Background: The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS. Objective: To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients. Methods: Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio (OR) and 95% confidence interval (CI) were calculated for association. Results: 43 reports were extracted (25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HER-15 family). The analysis showed an association between expression of all HERV families and MS. For HERV-W, adequate data was available for meta-analysis. Results from meta-analyses of HERV-W were OR = 22.66 (95%CI 6.32 to 81.20) from 4 studies investigating MSRV/HERV-W(MS-associated retrovirus) envelope mRNA in peripheral blood mononuclear cells, OR = 44.11 (95%CI 12.95 to 150.30) from 6 studies of MSRV/ HERV-W polymerase mRNA in serum/plasma and OR = 6.00 (95%CI 3.35 to 10.74) from 4 studies of MSRV/HERV-W polymerase mRNA in CSF. Public Library of Science 2017-02-16 Article PeerReviewed Morandi, Elena, Tanasescu, Radu, Tarlinton, Rachael E., Constantinescu, Cris S., Zhang, Weiya, Tench, Christopher R. and Gran, Bruno (2017) The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis. PLoS ONE, 12 (2). e0172415/1-e0172415/18. ISSN 1932-6203 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172415 doi:10.1371/journal.pone.0172415 doi:10.1371/journal.pone.0172415 |
| spellingShingle | Morandi, Elena Tanasescu, Radu Tarlinton, Rachael E. Constantinescu, Cris S. Zhang, Weiya Tench, Christopher R. Gran, Bruno The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis |
| title | The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis |
| title_full | The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis |
| title_fullStr | The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis |
| title_full_unstemmed | The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis |
| title_short | The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis |
| title_sort | association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis |
| url | https://eprints.nottingham.ac.uk/40630/ https://eprints.nottingham.ac.uk/40630/ https://eprints.nottingham.ac.uk/40630/ |