Measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks
Background:Because atopic dermatitis (AD) is a relapsing, remitting disease, assessing long‐term control is important. Well controlled weeks (WCWs) have been used to assess asthma long‐term control, but never validated for AD. Objectives: To assess feasibility, validity and interpretability of WCWs...
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40565/ |
| _version_ | 1848796088019976192 |
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| author | Langan, Sinéad M. Stuart, Beth Bradshaw, Lucy Schmitt, Jochen Williams, Hywel C. Thomas, Kim S. |
| author_facet | Langan, Sinéad M. Stuart, Beth Bradshaw, Lucy Schmitt, Jochen Williams, Hywel C. Thomas, Kim S. |
| author_sort | Langan, Sinéad M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background:Because atopic dermatitis (AD) is a relapsing, remitting disease, assessing long‐term control is important. Well controlled weeks (WCWs) have been used to assess asthma long‐term control, but never validated for AD.
Objectives: To assess feasibility, validity and interpretability of WCWs in AD patients.
Methods: Three studies of patients with moderate‐to‐severe AD including 4‐6 months of daily/weekly symptom and treatment use data were evaluated (Study A: n=336; Study B: n=60; Study C: n=224). WCWs were defined by worsening symptoms and increased medication use. Feasibility, construct validity and interpretability of WCWs were determined by assessing missing data, association with validated AD outcomes, and floor/ceiling effects. Analysis used linear and logistic regression.
Results: WCWs were feasible to collect ‐ 95.2% (study A) and 94.7% (study B) contributed data for at least half of the weekly data‐points, and 93.2% and 88.7% contributed to all data‐points up to 4 months. WCWs were significantly associated with validated AD severity instruments including patient-reported (POEM) and objective signs (EASI, TIS and SASSAD). The odds of experiencing a WCW if AD severity was clear/mild was 5.8 (95% confidence interval (CI) 3.5 to 9.7), 1.9 (95%CI 0.8 to 4.4) and 8.1 (95%CI 4.5 to 14.6) in Studies A, B and C, respectively. WCWs were associated with ceiling effects‐ 31.6% (study A) and 37.5% (study B) of participants had no WCWs for >90% of the time.
Conclusions: WCWs are valid and feasible for measuring long‐term control in AD trials. However, ceiling effects and burden of data collection may limit use. |
| first_indexed | 2025-11-14T19:42:25Z |
| format | Article |
| id | nottingham-40565 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:42:25Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-405652020-05-04T19:20:36Z https://eprints.nottingham.ac.uk/40565/ Measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks Langan, Sinéad M. Stuart, Beth Bradshaw, Lucy Schmitt, Jochen Williams, Hywel C. Thomas, Kim S. Background:Because atopic dermatitis (AD) is a relapsing, remitting disease, assessing long‐term control is important. Well controlled weeks (WCWs) have been used to assess asthma long‐term control, but never validated for AD. Objectives: To assess feasibility, validity and interpretability of WCWs in AD patients. Methods: Three studies of patients with moderate‐to‐severe AD including 4‐6 months of daily/weekly symptom and treatment use data were evaluated (Study A: n=336; Study B: n=60; Study C: n=224). WCWs were defined by worsening symptoms and increased medication use. Feasibility, construct validity and interpretability of WCWs were determined by assessing missing data, association with validated AD outcomes, and floor/ceiling effects. Analysis used linear and logistic regression. Results: WCWs were feasible to collect ‐ 95.2% (study A) and 94.7% (study B) contributed data for at least half of the weekly data‐points, and 93.2% and 88.7% contributed to all data‐points up to 4 months. WCWs were significantly associated with validated AD severity instruments including patient-reported (POEM) and objective signs (EASI, TIS and SASSAD). The odds of experiencing a WCW if AD severity was clear/mild was 5.8 (95% confidence interval (CI) 3.5 to 9.7), 1.9 (95%CI 0.8 to 4.4) and 8.1 (95%CI 4.5 to 14.6) in Studies A, B and C, respectively. WCWs were associated with ceiling effects‐ 31.6% (study A) and 37.5% (study B) of participants had no WCWs for >90% of the time. Conclusions: WCWs are valid and feasible for measuring long‐term control in AD trials. However, ceiling effects and burden of data collection may limit use. Elsevier 2017-12-01 Article PeerReviewed Langan, Sinéad M., Stuart, Beth, Bradshaw, Lucy, Schmitt, Jochen, Williams, Hywel C. and Thomas, Kim S. (2017) Measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks. Journal of Allergy and Clinical Immunology, 140 (6). pp. 1580-1586. ISSN 1097-6825 AD long‐term control outcome measures http://www.sciencedirect.com/science/article/pii/S0091674917306772 doi:10.1016/j.jaci.2017.02.043 doi:10.1016/j.jaci.2017.02.043 |
| spellingShingle | AD long‐term control outcome measures Langan, Sinéad M. Stuart, Beth Bradshaw, Lucy Schmitt, Jochen Williams, Hywel C. Thomas, Kim S. Measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks |
| title | Measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks |
| title_full | Measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks |
| title_fullStr | Measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks |
| title_full_unstemmed | Measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks |
| title_short | Measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks |
| title_sort | measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks |
| topic | AD long‐term control outcome measures |
| url | https://eprints.nottingham.ac.uk/40565/ https://eprints.nottingham.ac.uk/40565/ https://eprints.nottingham.ac.uk/40565/ |