High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end-stage liver disease

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High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end-stage liver disease

Background & Aims The high replication and mutation rate of hepatitis C virus (HCV) results in a heterogeneous population of viral sequences in vivo. HCV replicates in the liver and infected hepatocytes occur as foci surrounded by uninfected cells that may promote compartmentalization of vira...

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Main Authors:	Hedegaard, Ditte L., Tully, Damien C., Rowe, Ian A., Reynolds, Gary M., Bean, David J., Hu, Ke, Davis, Christopher, Wilhelm, Annika, Ogilvie, Colin B., Power, Karen A., Tarr, Alexander W., Kelly, Deirdre, Allen, Todd M., Balfe, Peter, McKeating, Jane A.
Format:	Article
Published:	Elsevier 2017
Subjects:	Hepatitis C; ESLD; Evolution; Compartmentalization; Innate immunity
Online Access:	https://eprints.nottingham.ac.uk/40558/

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