Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA

QR Code

Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA

Objectives: To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K, indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). Methods: Sera and clinical data were collected from 129 people (97...

Full description

Bibliographic Details
Main Authors:	Nwosu, Lilian Ngozi, Allen, Maximillian, Wyatt, L.A., Huebner, J.L., Chapman, Victoria, Walsh, David A., Kraus, Virginia
Format:	Article
Published:	Elsevier 2017
Subjects:	TRAcP5b; Subchondral bone; Biomarker; Osteoarthritis pain; Osteoclast
Online Access:	https://eprints.nottingham.ac.uk/40543/

Similar Items

Bone resorption marker and associated factors among postmenopausal Chinese women in senior citizen clubs in Kuala Lumpur and Selangor, Malaysia
by: Leiu, Kok Hong
Published: (2019)

Histopathological subgroups in knee osteoarthritis
by: Wyatt, L.A., et al.
Published: (2016)

The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain
by: Xu, L., et al.
Published: (2016)

New therapeutic targets for osteoarthritis pain
by: Walsh, David A., et al.
Published: (2017)

Structural and pain modifications in models of osteoarthritis
by: Nwosu, Lilian Ngozi
Published: (2015)

Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis
by: Prieto-Potin, Iván, et al.
Published: (2015)

Epidemiology and genetics of catastrophizing and pain in OA
by: Harvey, Hollie
Published: (2017)

Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by directional fractal signature method
by: Wolski, Marcin, et al.
Published: (2010)

Early tibial subchondral bone texture changes after arthroscopic partial meniscectomy in knees without radiographic OA: A prospective cohort study
by: Wolski, Marcin, et al.
Published: (2020)

Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA)
by: Nwosu, Lilian Ngozi, et al.
Published: (2016)

Directional fractal signature analysis of trabecular bone: evaluation of different methods to detect early osteoarthritis in knee radiographs
by: Wolski, Marcin, et al.
Published: (2009)

Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat
by: Sagar, Devi Rani, et al.
Published: (2015)

Automated Selection of Trabecular Bone Regions in Knee Radiographs
by: Podsiadlo, P, et al.
Published: (2008)

An investigation of the influence of co-morbid anxiety on functional connectivity changes in the MIA model of OA pain
by: Lillywhite, Amanda
Published: (2020)

Effectiveness of internet-based exercises aimed at treating knee osteoarthritis (iBEAT-OA): a randomized clinical trial
by: Gohir, Sameer
Published: (2021)

Structural associations of symptomatic knee osteoarthritis
by: Wyatt, Laura A.
Published: (2015)

Jumlah pengambilan kalori, kalsium dan protein serta hubungannya dengan kepadatan mineral tulang dalam kalangan warga tua
by: Mohd Din, Feaizul
Published: (2018)

Therapeutic targeting of the leukaemia microenvironment
by: Kuek, V., et al.
Published: (2021)

Role of plasma membrane transporters (N+/H+ and HCO3-) in mediating mammalian longitudinal bone growth and fracture healing
by: Abdul, Abubakar Adamu
Published: (2016)

Association of Nutritional, Functional Status and Lifestyle Habits with Bone Health Status Amongst the Institutionalized Elderly
by: Tee, Chin Kim
Published: (2007)

Efficacy of channa striatus bloch aqueous extract and zerumbone in alleviating induced knee osteoarthritis in rats
by: Al-Saffar, Fayak Jabbar Taqi
Published: (2011)

Repair of Normal and Pathologic Osseous Defects Using Bone Tissue Engineering
by: Kaveh, Kamran
Published: (2010)

Analysis of candidate genes within the 3p14-p22 region of the human genome for association with bone mineral density phenotypes
by: Mullin, Benjamin H
Published: (2011)

Efficacy of Labisia pumila Benth. & Hook. f. and Vernonia amygdalina Delile leaf extracts in alleviating postmenopausal osteoarthritis in rats
by: Madzuki, Iffah Nadhira
Published: (2018)

Synthesis and in vitro evaluation of bone-seeking superparamagnetic iron oxide nanoparticles as contrast agents for imaging bone metabolic activity
by: Panahifar, A., et al.
Published: (2013)

Fully automated bone age assessment using bag of features on hand radiograph images
by: Abbas, Hamzah Fadhil
Published: (2019)

Association between bone characteristics and cardiovascular risk factors among adults in selected urban areas in Selangor, Malaysia
by: Mohamad Ismuddin, Safarina
Published: (2021)

Isolation And Characterization Of Mesenchymal Cells From Human Bone Marrow And Their Development Into Bone Cells
by: Shahidan, Wan Nazatul Shima
Published: (2007)

Development and evaluation of novel alginate/cockle shell powder nano-biocomposite porous 3D scaffold for bone repair
by: Bharatham, B. Hemabarathy
Published: (2013)

sTREM-1 is elevated in cystic fibrosis and correlates with proteases
by: Forrester, D.L., et al.
Published: (2017)

THE IDENTIFICATION OF BIOMARKERS TO PREDICT RESPONSE TO TREATMENTS IN ASTHMA
by: Lissa, Sutherland
Published: (2019)

Proteomic and transcriptomic analyses of protein biomarkers during early hyperinfection in strongyloidiasis
by: Al-Zihiry, Khalid Jameel Kadhim
Published: (2016)

Expression, Characterization, and Evaluation of a RANK-binding Single Chain Fraction Variable: An Osteoclast Targeting Drug Delivery Strategy
by: Newa, M., et al.
Published: (2014)

Evaluation of osteogenic potential of demineralized bone matrix in pigeon (Columba livia Gmelin)
by: Sanaei, Mohamad Reza
Published: (2011)

Healing of surgically created ulna defect treated with bone graft substitutes in a pigeon model
by: Ahmed, Tunio
Published: (2013)

Preparation and characterization of [68Ga]NODAGA-Pamidronic acid for pet bone cancer imaging
by: Mohd Ashhar, Zarif Naim
Published: (2020)

Bone turnover markers (P1NP, CTX) and sphingosine-1- phosphate (S1P) in determining bone health among chinese adult residents of Puchong and Kajang in Selangor, Malaysia
by: Shahifar, Nasrin
Published: (2019)

The experience of living with knee osteoarthritis: exploring illness and treatment beliefs through thematic analysis
by: Pouli, Nektaria, et al.
Published: (2013)

Articular cartilage morphology and synovial fluid protein biomarkers in the monosodium iodoacetate-induced osteoarthritis rabbit model
by: Tan, Wei Miao @ Rachel
Published: (2017)

Influence of ARHGEF3 and RHOA Knockdown on ACTA2 and Other Genes in Osteoblasts and Osteoclasts
by: Mullin, B., et al.
Published: (2014)