Novel strategies for assessing platelet reactivity
There are many approaches to assessing platelet reactivity and many uses for such measurements. Initially, measurements were based on the ability of platelets separated from other blood cells to aggregate together following activation with an appropriate ‘aggregating agent’. Later, measurements of p...
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| Format: | Article |
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Future Medicine
2017
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| Online Access: | https://eprints.nottingham.ac.uk/40527/ |
| _version_ | 1848796078941405184 |
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| author | Algahtani, Mohammad Heptinstall, Stan |
| author_facet | Algahtani, Mohammad Heptinstall, Stan |
| author_sort | Algahtani, Mohammad |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | There are many approaches to assessing platelet reactivity and many uses for such measurements. Initially, measurements were based on the ability of platelets separated from other blood cells to aggregate together following activation with an appropriate ‘aggregating agent’. Later, measurements of platelet aggregation in blood itself were performed, and this led to a point-of-care approach to platelet function testing. Measurement of secretory activity through the appearance of the activation marker P-selectin on platelets now provides an alternative approach, which enables remote testing.
Measurement of vasodilator-stimulated phosphoprotein phosphorylation is also moving toward application in situations remote from the testing laboratory. Here we provide an overview of the various approaches that are now available, assess their advantages and disadvantages, and describe some of the clinical situations in which they are being used. |
| first_indexed | 2025-11-14T19:42:16Z |
| format | Article |
| id | nottingham-40527 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:42:16Z |
| publishDate | 2017 |
| publisher | Future Medicine |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-405272020-05-04T18:22:42Z https://eprints.nottingham.ac.uk/40527/ Novel strategies for assessing platelet reactivity Algahtani, Mohammad Heptinstall, Stan There are many approaches to assessing platelet reactivity and many uses for such measurements. Initially, measurements were based on the ability of platelets separated from other blood cells to aggregate together following activation with an appropriate ‘aggregating agent’. Later, measurements of platelet aggregation in blood itself were performed, and this led to a point-of-care approach to platelet function testing. Measurement of secretory activity through the appearance of the activation marker P-selectin on platelets now provides an alternative approach, which enables remote testing. Measurement of vasodilator-stimulated phosphoprotein phosphorylation is also moving toward application in situations remote from the testing laboratory. Here we provide an overview of the various approaches that are now available, assess their advantages and disadvantages, and describe some of the clinical situations in which they are being used. Future Medicine 2017-01-01 Article PeerReviewed Algahtani, Mohammad and Heptinstall, Stan (2017) Novel strategies for assessing platelet reactivity. Future Cardiology, 13 (1). pp. 33-47. ISSN 1479-6678 aspirin ; flow cytometry ; light transmission aggregometry ; LTA ; MEA ; multiplate electrode aggregometry ; P-selectin ; P2Y12 antagonists ; platelet aggregation ; platelet reactivity ; VASP phosphorylation ; VerifyNow http://www.futuremedicine.com/doi/10.2217/fca-2016-0054 doi:10.2217/fca-2016-0054 doi:10.2217/fca-2016-0054 |
| spellingShingle | aspirin ; flow cytometry ; light transmission aggregometry ; LTA ; MEA ; multiplate electrode aggregometry ; P-selectin ; P2Y12 antagonists ; platelet aggregation ; platelet reactivity ; VASP phosphorylation ; VerifyNow Algahtani, Mohammad Heptinstall, Stan Novel strategies for assessing platelet reactivity |
| title | Novel strategies for assessing platelet reactivity |
| title_full | Novel strategies for assessing platelet reactivity |
| title_fullStr | Novel strategies for assessing platelet reactivity |
| title_full_unstemmed | Novel strategies for assessing platelet reactivity |
| title_short | Novel strategies for assessing platelet reactivity |
| title_sort | novel strategies for assessing platelet reactivity |
| topic | aspirin ; flow cytometry ; light transmission aggregometry ; LTA ; MEA ; multiplate electrode aggregometry ; P-selectin ; P2Y12 antagonists ; platelet aggregation ; platelet reactivity ; VASP phosphorylation ; VerifyNow |
| url | https://eprints.nottingham.ac.uk/40527/ https://eprints.nottingham.ac.uk/40527/ https://eprints.nottingham.ac.uk/40527/ |