Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein

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Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein

The multidrug resistance P-glycoprotein (P-gp) is characterised by the ability to bind and/or transport an astonishing array of drugs. This poly-specificity is imparted by at least four pharmacologically distinct binding sites within the transmembrane domain. Whether or not these sites are spatially...

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Bibliographic Details
Main Authors:	Mittra, Rituparna, Pavy, Megan, Subramanian, Nanditha, George, Anthony M., O'Mara, Megan L., Kerr, Ian D., Callaghan, Richard
Format:	Article
Published:	Elsevier 2017
Subjects:	P-glycoprotein; Multidrug resistance; Membrane transport; ABC protein; Cancer chemotherapy
Online Access:	https://eprints.nottingham.ac.uk/40519/

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